Bone attachment to hydroxyapatite coated polymers.

P S Boone, M C Zimmerman, E Gutteling, C K Lee, J R Parsons, N Langrana
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Abstract

Bone attachment to two classes of hydroxyapatite (HA) coated polymers was evaluated mechanically and histologically. Particulate HA was molded into the surface of thermoplastic implants and cast into the surface of thermoset implants. Coated and uncoated implants of both types were implanted in the distal femurs of rabbits for four and twelve weeks. After sacrifice, the bone/implant interface was evaluated mechanically via a push-out test with a servohydraulic test system. Paired statistical analysis revealed significantly greater shear strengths for coated vs. uncoated implants for both polymer systems at both time periods. Mixed mode of failure occurred with particle removal from the polymer surface and from the bone. One animal at each time period was saved for histology. Histology at both time periods indicated direct bone apposition to the HA coating as compared to a fibrous encapsulation about the uncoated implants. This was confirmed with backscatter scanning electron microscopy and scanning acoustic microscopy. Hydroxyapatite coatings significantly improve the bond strength between polymers and bone by allowing direct bone apposition and some mechanical interlocking with the bone.

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骨附着羟基磷灰石涂层聚合物。
骨附着于两类羟基磷灰石(HA)涂层聚合物进行机械和组织学评价。微粒羟基磷灰石被模压到热塑性植入物的表面,并浇铸到热固性植入物的表面。两种类型的包被和未包被植入物分别植入兔股骨远端4周和12周。牺牲后,通过伺服液压测试系统进行推出测试,对骨/植入物界面进行机械评估。配对统计分析显示,在两个时间段内,两种聚合物体系的涂覆植入物与未涂覆植入物的抗剪强度均显著提高。混合模式的失败发生在颗粒从聚合物表面和骨骼中去除。每个时间段保留一只动物进行组织学检查。两个时间段的组织学显示,与未涂膜种植体的纤维包封相比,羟基磷灰石涂层与骨直接接触。后向散射扫描电子显微镜和扫描声学显微镜证实了这一点。羟基磷灰石涂层通过允许骨的直接接触和与骨的机械联锁,显著提高聚合物与骨之间的结合强度。
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