Eryptosis: a driver of anemia in chronic kidney disease.

IF 2.2 3区医学 Q3 PERIPHERAL VASCULAR DISEASE Current Opinion in Nephrology and Hypertension Pub Date : 2024-03-01 Epub Date: 2023-11-17 DOI:10.1097/MNH.0000000000000957

Rosi Bissinger, Syed M Qadri, Ferruh Artunc

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Abstract

Purpose of review: Anemia, characterized by a reduction in red blood cell (RBC) count or hemoglobin concentration, commonly accompanies chronic kidney disease (CKD), significantly impacting patients' quality of life. This review delves into the multifaceted nature of anemia in CKD, with a focus on novel mechanisms, particularly the dysregulation of eryptosis or programmed cell death of RBCs, leading to shortened RBC lifespan.

Recent findings: Recent studies in CKD patients and mouse models revealed that eryptosis, driven by factors such as uremic toxins, inflammation, and imbalances in calcium homeostasis, plays a pivotal role in the development of renal anemia. Dysregulated eryptosis results in premature RBC destruction, exacerbating the hypoproliferative character of anemia in CKD.

Summary: Recognizing the intricate relationship between eryptosis and anemia in CKD opens promising prospects for improving patient outcomes and enhancing our understanding of this complex condition. Future research and therapeutic development in this area hold the potential to improve anemia treatment of CKD patients.

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贫血:慢性肾脏疾病贫血的驱动因素。

回顾目的:以红细胞(RBC)计数或血红蛋白浓度降低为特征的贫血，通常伴随慢性肾脏疾病(CKD)，显著影响患者的生活质量。这篇综述深入探讨了CKD中贫血的多面性，重点关注了新的机制，特别是红细胞红细胞凋亡或程序性细胞死亡的失调，导致红细胞寿命缩短。近期发现:近期对CKD患者和小鼠模型的研究表明，由尿毒症毒素、炎症和钙稳态失衡等因素驱动的脓毒症在肾性贫血的发展中起着关键作用。红细胞增生失调导致红细胞过早破坏，加重慢性肾病贫血的低增殖特征。总结:认识到慢性肾病患者贫血和贫血之间的复杂关系，为改善患者预后和增强我们对这一复杂疾病的理解开辟了广阔的前景。该领域未来的研究和治疗发展有望改善慢性肾病患者的贫血治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Nephrology and Hypertension 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

6.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： A reader-friendly resource, Current Opinion in Nephrology and Hypertension provides an up-to-date account of the most important advances in the field of nephrology and hypertension. Each issue contains either two or three sections delivering a diverse and comprehensive coverage of all the key issues, including pathophysiology of hypertension, circulation and hemodynamics, and clinical nephrology. Current Opinion in Nephrology and Hypertension is an indispensable journal for the busy clinician, researcher or student.

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