Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-11-16 DOI:10.3390/hematolrep15040064
Nisha Hariharan, Alisha Kabadi, Michelle Don, Mazen Odish, Benjamin Heyman
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Abstract

Diffuse large B-cell lymphoma (DLBCL) and angioimmunoblastic T-cell lymphoma (AITL) are two subtypes of non-Hodgkin lymphoma (NHL). The simultaneous occurrence of DLBCL and AITL in a composite lymphoma is very rare, and there are no established treatment regimens. We present the case of an 85-year-old male admitted to the intensive care unit with distributive shock, lymphocytosis, and lymphadenopathy, who was subsequently diagnosed with composite AITL and DLBCL, and treated with brentuximab vedotin (BV) and rituximab. To our knowledge, this is the first case of composite lymphoma presenting with distributive shock and treated with BV and rituximab, with successful resolution of shock.

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复合血管免疫母细胞t细胞淋巴瘤和弥漫性大b细胞淋巴瘤表现为分布性休克。
弥漫性大b细胞淋巴瘤(DLBCL)和血管免疫母细胞t细胞淋巴瘤(AITL)是非霍奇金淋巴瘤(NHL)的两种亚型。复合淋巴瘤同时发生DLBCL和AITL是非常罕见的,目前还没有确定的治疗方案。我们报告一例85岁男性患者,因分布性休克、淋巴细胞增多和淋巴结病被送入重症监护室,随后被诊断为混合性AITL和DLBCL,并接受brentuximab vedotin (BV)和rituximab治疗。据我们所知,这是第一例以分布性休克为表现的复合性淋巴瘤,经BV和利妥昔单抗治疗,休克得到了成功的解决。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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