Illuminating Airway Nerve Structure and Function in Chronic Cough.

IF 4.6 2区 医学 Q1 RESPIRATORY SYSTEM Lung Pub Date : 2023-12-01 Epub Date: 2023-11-21 DOI:10.1007/s00408-023-00659-x
James Kornfield, Ubaldo De La Torre, Emily Mize, Matthew G Drake
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Abstract

Airway nerves regulate vital airway functions including bronchoconstriction, cough, and control of respiration. Dysregulation of airway nerves underlies the development and manifestations of airway diseases such as chronic cough, where sensitization of neural pathways leads to excessive cough triggering. Nerves are heterogeneous in both expression and function. Recent advances in confocal imaging and in targeted genetic manipulation of airway nerves have expanded our ability to visualize neural organization, study neuro-immune interactions, and selectively modulate nerve activation. As a result, we have an unprecedented ability to quantitatively assess neural remodeling and its role in the development of airway disease. This review highlights our existing understanding of neural heterogeneity and how advances in methodology have illuminated airway nerve morphology and function in health and disease.

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阐明慢性咳嗽的气道神经结构和功能。
气道神经调节重要的气道功能,包括支气管收缩、咳嗽和呼吸控制。气道神经的失调是气道疾病的发展和表现的基础,如慢性咳嗽,其中神经通路的敏化导致过度的咳嗽触发。神经在表达和功能上都是异质的。最近在共聚焦成像和气道神经靶向遗传操作方面的进展扩大了我们可视化神经组织、研究神经免疫相互作用和选择性调节神经激活的能力。因此,我们有了前所未有的能力来定量评估神经重塑及其在气道疾病发展中的作用。这篇综述强调了我们对神经异质性的现有理解,以及方法的进步如何阐明了健康和疾病中气道神经的形态和功能。
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来源期刊
Lung
Lung 医学-呼吸系统
CiteScore
9.10
自引率
10.00%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.
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