Current Status of Microneedle Array Technology for Therapeutic Delivery: From Bench to Clinic.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Biotechnology Pub Date : 2024-12-01 Epub Date: 2023-11-21 DOI:10.1007/s12033-023-00961-2

Chiranjib Chakraborty, Manojit Bhattacharya, Sang-Soo Lee

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Abstract

In recent years, microneedle (MN) patches have emerged as an alternative technology for transdermal delivery of various drugs, therapeutics proteins, and vaccines. Therefore, there is an urgent need to understand the status of MN-based therapeutics. The article aims to illustrate the current status of microneedle array technology for therapeutic delivery through a comprehensive review. However, the PubMed search was performed to understand the MN's therapeutics delivery status. At the same time, the search shows the number no of publications on MN is increasing (63). The search was performed with the keywords "Coated microneedle," "Hollow microneedle," "Dissolvable microneedle," and "Hydrogel microneedle," which also shows increasing trend. Similarly, the article highlighted the application of different microneedle arrays for treating different diseases. The article also illustrated the current status of different phases of MN-based therapeutics clinical trials. It discusses the delivery of different therapeutic molecules, such as drug molecule delivery, using microneedle array technology. The approach mainly discusses the delivery of different therapeutic molecules. The leading pharmaceutical companies that produce the microneedle array for therapeutic purposes have also been discussed. Finally, we discussed the limitations and future prospects of this technology.

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微针阵列治疗递送技术的现状:从实验室到临床。

近年来，微针(MN)贴片已成为各种药物、治疗药物、蛋白质和疫苗经皮递送的替代技术。因此，迫切需要了解基于mn的治疗方法的现状。本文旨在通过全面的综述来说明微针阵列技术用于治疗递送的现状。然而，PubMed搜索是为了了解MN的治疗递送状态。同时，检索显示MN的出版物数量在增加(63)。关键词“包覆微针”、“空心微针”、“可溶解微针”、“水凝胶微针”的搜索量也呈上升趋势。同样，文章强调了不同微针阵列在治疗不同疾病中的应用。文章还阐述了目前基于mn的治疗学临床试验的不同阶段的现状。讨论了利用微针阵列技术递送不同的治疗分子，如药物分子。该方法主要讨论不同治疗分子的递送。还讨论了生产用于治疗目的的微针阵列的领先制药公司。最后，我们讨论了该技术的局限性和未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biotechnology 医学-生化与分子生物学

CiteScore

4.10

自引率

3.80%

发文量

165

审稿时长

6 months

期刊介绍： Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.