[Searching for Evidence: A Systematic Review of the Pathology of Lipoedema].

IF 0.4 4区 医学 Q4 SURGERY Handchirurgie Mikrochirurgie Plastische Chirurgie Pub Date : 2023-12-01 Epub Date: 2023-11-20 DOI:10.1055/a-2183-7414
Sarah Funke, Constanze Kuhlmann, Sara Taha, Benedikt Fuchs, Paul Severin Wiggenhauser, Riccardo E Giunta
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Abstract

Background: Lipoedema is a symmetrically localised, painful hypertrophy of subcutaneous adipose tissue in the extremities with marked disproportion to the trunk, and almost exclusively affects females. Despite being first described over 80 years ago, the aetiology and pathogenesis of the disease are largely unknown and are currently the subject of intensive research efforts.

Methods: To summarise the current evidence-based literature on the cellular pathologies and aetiology of lipoedema, a PRISMA-based systematic review was conducted within the National Library of Medicine and Cochrane databases.

Results: A total of 53 studies were identified and included in this review. The results were classified and summarised into categories.

Conclusion: Although there has been a significant increase in research activity and recent publication of extensive studies with a histological and molecular genetic focus, the fundamental aetiology and pathology of lipoedema remains largely unclear. The current data shows discrepancies across studies, particularly with regard to the "oedematous" component of lipoedema. The frequently present comorbidities "lymphoedema" and "obesity", primarily in advanced stages of lipoedema, complicate the diagnostic differentiation and clear definition of study cohorts in scientific research.

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[寻找证据:脂水肿病理的系统综述]。
背景:脂肪水肿是四肢皮下脂肪组织的一种局部对称、疼痛性肥大,与躯干明显不成比例,几乎只发生在女性身上。尽管在80多年前首次被描述,但该病的病因和发病机制在很大程度上是未知的,目前是深入研究的主题。方法:为了总结目前关于脂肪水肿的细胞病理学和病因学的循证文献,我们在美国国家医学图书馆和Cochrane数据库中进行了基于prisma的系统综述。结果:本综述共纳入53项研究。结果被分类和总结成几类。结论:尽管在组织学和分子遗传学方面的研究活动和最近发表的大量研究显著增加,但脂肪水肿的基本病因和病理在很大程度上仍不清楚。目前的数据显示了不同研究之间的差异,特别是关于脂水肿的“水肿”成分。常出现的合并症“淋巴水肿”和“肥胖”,主要发生在脂水肿的晚期,使科学研究中的诊断鉴别和研究队列的明确定义复杂化。
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来源期刊
CiteScore
1.00
自引率
16.70%
发文量
85
审稿时长
6-12 weeks
期刊介绍: In Originalarbeiten und Fallberichten finden Sie die neuesten Informationen über: Diagnostik Verfahrenswahl state of the art / neueste Techniken rekonstruktive Verfahren Behandlung infolge von Traumata oder OP Bewertung der Ergebnisse Klinische Forschung Interessante Darstellung der neuesten Erkenntnisse in Originalarbeiten und Fallberichten. Exzellent veranschaulicht durch ein klares Layout und reiche Bebilderung. Überzeugen Sie sich selbst! Organschaften Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie, Deutschen Gesellschaft für Handchirurgie und Österreichischen Gesellschaft für Handchirurgie Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der peripheren Nerven und Gefäße Organ der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen
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[Palmar Displacement in Distal Radius Fractures following Extension Injuries of the Wrist]. [Dorsal Screw Osteosynthesis of a Scaphoid Nonunion associated with Congenital Scaphotrapezial and Lunotriquetral Coalitions: A Case Report]. [Autologous Breast Reconstruction and Radiotherapy: Consensus Report of the German-Speaking Society for Reconstructive Microsurgery (GSRM)]. [Commentary on the Article of Philipp Moog, Edith Gawlik, Stefan Eisenreich et al. The Cost of Lipedema Treatment Exceeds the DRG Revenues - Evaluation of the Surgical Treatment Costs Of Lipedema (Stage III) at a German University Clinic]. [The Cost of Lipoedema Treatment Exceeds the DRG Revenues - Evaluation of the Surgical Treatment Costs of Lipoedema (Stage III) at a German University Clinic].
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