Sarah Funke, Constanze Kuhlmann, Sara Taha, Benedikt Fuchs, Paul Severin Wiggenhauser, Riccardo E Giunta
{"title":"[Searching for Evidence: A Systematic Review of the Pathology of Lipoedema].","authors":"Sarah Funke, Constanze Kuhlmann, Sara Taha, Benedikt Fuchs, Paul Severin Wiggenhauser, Riccardo E Giunta","doi":"10.1055/a-2183-7414","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Lipoedema is a symmetrically localised, painful hypertrophy of subcutaneous adipose tissue in the extremities with marked disproportion to the trunk, and almost exclusively affects females. Despite being first described over 80 years ago, the aetiology and pathogenesis of the disease are largely unknown and are currently the subject of intensive research efforts.</p><p><strong>Methods: </strong>To summarise the current evidence-based literature on the cellular pathologies and aetiology of lipoedema, a PRISMA-based systematic review was conducted within the National Library of Medicine and Cochrane databases.</p><p><strong>Results: </strong>A total of 53 studies were identified and included in this review. The results were classified and summarised into categories.</p><p><strong>Conclusion: </strong>Although there has been a significant increase in research activity and recent publication of extensive studies with a histological and molecular genetic focus, the fundamental aetiology and pathology of lipoedema remains largely unclear. The current data shows discrepancies across studies, particularly with regard to the \"oedematous\" component of lipoedema. The frequently present comorbidities \"lymphoedema\" and \"obesity\", primarily in advanced stages of lipoedema, complicate the diagnostic differentiation and clear definition of study cohorts in scientific research.</p>","PeriodicalId":55075,"journal":{"name":"Handchirurgie Mikrochirurgie Plastische Chirurgie","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Handchirurgie Mikrochirurgie Plastische Chirurgie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/a-2183-7414","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/20 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Lipoedema is a symmetrically localised, painful hypertrophy of subcutaneous adipose tissue in the extremities with marked disproportion to the trunk, and almost exclusively affects females. Despite being first described over 80 years ago, the aetiology and pathogenesis of the disease are largely unknown and are currently the subject of intensive research efforts.
Methods: To summarise the current evidence-based literature on the cellular pathologies and aetiology of lipoedema, a PRISMA-based systematic review was conducted within the National Library of Medicine and Cochrane databases.
Results: A total of 53 studies were identified and included in this review. The results were classified and summarised into categories.
Conclusion: Although there has been a significant increase in research activity and recent publication of extensive studies with a histological and molecular genetic focus, the fundamental aetiology and pathology of lipoedema remains largely unclear. The current data shows discrepancies across studies, particularly with regard to the "oedematous" component of lipoedema. The frequently present comorbidities "lymphoedema" and "obesity", primarily in advanced stages of lipoedema, complicate the diagnostic differentiation and clear definition of study cohorts in scientific research.
期刊介绍:
In Originalarbeiten und Fallberichten finden Sie die neuesten Informationen über:
Diagnostik
Verfahrenswahl
state of the art / neueste Techniken
rekonstruktive Verfahren
Behandlung infolge von Traumata oder OP
Bewertung der Ergebnisse
Klinische Forschung
Interessante Darstellung der neuesten Erkenntnisse in Originalarbeiten und Fallberichten. Exzellent
veranschaulicht durch ein klares Layout und reiche Bebilderung. Überzeugen Sie sich selbst!
Organschaften
Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie, Deutschen Gesellschaft für Handchirurgie und Österreichischen Gesellschaft für Handchirurgie
Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der peripheren Nerven und Gefäße
Organ der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen