A modification of the rat kidney transplantation model: reduction of experimental animals.

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01
P Vogt, A Lipécz, K Wähling
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Abstract

Inbred rats display several abnormalities of the renal arteries, which are relevant for the technique used in the kidney transplantation model. After analysis of anatomical variations of renal vascular supply in inbred Lewis rats we describe an improved standardized technique of bilateral kidney grafting. After harvesting both kidneys from the donor animal they can be transplanted into 2 recipient animals. That allows to save up to 50% of donor animals.

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大鼠肾移植模型的改进:减少实验动物。
近交大鼠表现出几种肾动脉异常,这与肾移植模型中使用的技术有关。在分析了近交系Lewis大鼠肾血管供应的解剖学变异后,我们描述了一种改进的标准化双侧肾移植技术。从供体动物身上取下两个肾脏后,它们可以移植到2个受体动物身上。这可以节省多达50%的捐赠动物。
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