The effect of acarbose on lipid profiles in adults: a systematic review and meta-analysis of randomized clinical trials.

IF 2.8 3区 医学 Q2 PHARMACOLOGY & PHARMACY BMC Pharmacology & Toxicology Pub Date : 2023-11-22 DOI:10.1186/s40360-023-00706-6
Mohsen Yousefi, Sahand Tehrani Fateh, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Samira Rastgoo, Reza Bagher, Alireza Khadem, Farideh Shiraseb, Omid Asbaghi
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Abstract

Purpose: Dyslipidemia, characterized by elevated levels of triglycerides (TG), low-density lipoprotein (LDL), total cholesterol (TC), and reduced levels of high-density lipoprotein (HDL), is a major risk factor for cardiovascular diseases (CVD). Several studies have shown the potential of acarbose in improving serum lipid markers. However, there have been conflicting results on the topic in adults. Therefore, a comprehensive systematic review and meta-analysis was conducted to assess the impact of acarbose on lipid profiles.

Methods: The random-effects approach was used to combine the data, and the results were provided as weighted mean difference (WMD) with 95% confidence intervals (CI).

Results: Our meta-analysis included a total of 74 studies with a combined sample size of 7046 participants. The results of the analysis showed that acarbose resulted in a reduction in levels of TG (WMD = - 13.43 mg/dl, 95% CI: - 19.20, - 7.67; P < 0.001) and TC (WMD = - 1.93 mg/dl, 95% CI: - 3.71, - 0.15; P = 0.033), but did not affect other lipid markers. When conducting a nonlinear dose-response analysis, we found that acarbose was associated with an increase in levels of HDL (coefficients = 0.50, P = 0.012), with the highest increase observed at a dosage of 400 mg/d. Furthermore, our findings suggested a non-linear relationship between the duration of the intervention and TC (coefficients = - 18.00, P = 0.032), with a decline observed after 50 weeks of treatment.

Conclusion: The findings of this study suggest that acarbose can reduce serum levels of TG and TC. However, no significant effects were observed on LDL or HDL levels.

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阿卡波糖对成人血脂的影响:随机临床试验的系统回顾和荟萃分析。
目的:血脂异常以甘油三酯(TG)、低密度脂蛋白(LDL)、总胆固醇(TC)水平升高和高密度脂蛋白(HDL)水平降低为特征,是心血管疾病(CVD)的主要危险因素。几项研究表明,阿卡波糖有改善血脂指标的潜力。然而,关于成人这个话题的研究结果却相互矛盾。因此,我们进行了一项全面的系统评价和荟萃分析,以评估阿卡波糖对血脂的影响。方法:采用随机效应法对资料进行合并,结果采用加权平均差(WMD), 95%可信区间(CI)。结果:我们的荟萃分析共纳入74项研究,总样本量为7046名参与者。分析结果显示,阿卡波糖导致TG水平降低(WMD = - 13.43 mg/dl, 95% CI: - 19.20, - 7.67;结论:阿卡波糖具有降低血清TG和TC水平的作用。然而,对低密度脂蛋白或高密度脂蛋白水平没有显著影响。
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来源期刊
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology PHARMACOLOGY & PHARMACYTOXICOLOGY&nb-TOXICOLOGY
CiteScore
4.80
自引率
0.00%
发文量
87
审稿时长
12 weeks
期刊介绍: BMC Pharmacology and Toxicology is an open access, peer-reviewed journal that considers articles on all aspects of chemically defined therapeutic and toxic agents. The journal welcomes submissions from all fields of experimental and clinical pharmacology including clinical trials and toxicology.
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