Serum levels of sonic hedgehog in patients with IgA nephropathy are closely associated with intrarenal arteriolar lesions

IF 2.5 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY Clinical biochemistry Pub Date : 2023-11-19 DOI:10.1016/j.clinbiochem.2023.110687
Fei Peng , Lingling Wu , Jie Wu , Shuwei Duan , Jiayi He , Pu Chen , Peng Wang , Jiaona Liu , Guangyan Cai , Chuyue Zhang , Xiangmei Chen
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Abstract

Background

Intrarenal arteriolar disease is a major risk factor for poor prognosis in immunoglobulin A nephropathy (IgAN). The morphologic factor sonic hedgehog (SHH) plays an important role in a variety of vascular diseases, so it may be directly or indirectly involved in the process of renal arteriolar disease. The purpose of this study was to investigate the correlation between serum SHH levels and renal arteriole disease in patients with IgAN.

Methods

Subjects with primary IgAN diagnosed by renal biopsy performed between October 2018 and August 2019 at the First Medical Center of the Chinese PLA General Hospital were recruited. Blood specimens were collected from the patients within 1 week before renal biopsy after they signed an informed consent form, and healthy controls were recruited for blood specimen collection during the same period. The concentration of serum SHH was measured by enzyme-linked immunosorbent assay in this population.

Results

Serum SHH levels were significantly lower in the IgAN group than in the control group. 41 of the 94 subjects diagnosed with IgAN had severe renal arteriolosclerosis and, compared to their less severely affected counterparts, were older, more hypertensive, and characterized by lower levels of SHH, higher levels of tubular atrophy/interstitial fibrosis and a higher Lee's classification. Serum SHH concentration was found to be an independent predictor of severe intrarenal arteriolosclerosis in IgAN subjects after correction using multivariate analysis.

Conclusion

In this study, serum SHH levels were found to be significantly lower in patients with IgAN than in healthy subjects. Serum SHH may serve as a noninvasive biomarker of intrarenal arteriolosclerosis in patients with IgAN.

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IgA肾病患者血清超音hedgehog基因水平与肾内小动脉病变密切相关。
背景:肾内小动脉疾病是导致免疫球蛋白a肾病(IgAN)预后不良的主要危险因素。形态因子sonic hedgehog (SHH)在多种血管疾病中发挥重要作用,可能直接或间接参与肾小动脉疾病的发生过程。本研究的目的是探讨IgAN患者血清SHH水平与肾小动脉疾病的相关性。方法:招募2018年10月至2019年8月在中国人民解放军总医院第一医疗中心行肾活检诊断为原发性IgAN的受试者。患者签署知情同意书后,于肾活检前1周内采血,同期招募健康对照者采血。采用酶联免疫吸附法测定该人群的血清SHH浓度。结果:IgAN组血清SHH水平明显低于对照组。94名被诊断为IgAN的受试者中有41名患有严重的肾小动脉硬化,与受影响较轻的受试者相比,他们年龄更大,高血压程度更高,其特征是SHH水平较低,小管萎缩/间质纤维化水平较高,Lee's分级较高。经多变量分析校正后,发现血清SHH浓度是IgAN受试者严重肾内小动脉硬化的独立预测因子。结论:在本研究中,IgAN患者血清SHH水平明显低于健康受试者。血清SHH可作为IgAN患者肾内小动脉硬化的无创生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical biochemistry
Clinical biochemistry 医学-医学实验技术
CiteScore
5.10
自引率
0.00%
发文量
151
审稿时长
25 days
期刊介绍: Clinical Biochemistry publishes articles relating to clinical chemistry, molecular biology and genetics, therapeutic drug monitoring and toxicology, laboratory immunology and laboratory medicine in general, with the focus on analytical and clinical investigation of laboratory tests in humans used for diagnosis, prognosis, treatment and therapy, and monitoring of disease.
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