{"title":"Non-alcoholic fatty liver disease and periodontal disease: A systematic review and meta-analysis of cross-sectional studies","authors":"Inácio Lima Silva Aguiar , Larissa Souza Santos-Lins , Rebeca Brasil-Oliveira , Helma Pinchemel Cotrim , Liliane Lins-Kusterer","doi":"10.1016/j.ajg.2023.09.005","DOIUrl":null,"url":null,"abstract":"<div><p><span>Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease<span>, comprising hepatic steatosis<span>, and non-alcoholic steatohepatitis. Periodontal disease<span> (PD) may be a risk factor for the evolution of liver cirrhosis. This study aimed to evaluate the association between NAFLD and PD.</span></span></span></span> <span>We searched in Pubmed, Scopus, Cochrane, and Lilacs databases with descriptors (Non-alcoholic Fatty Liver Disease OR (non-alcoholic AND Fatty Liver AND disease) OR Nonalcoholic Steatohepatitis) AND (Periodontal Disease OR Gingivitis<span> OR Periodontitis) from January 2021 to September 2021. We selected, by the abstract, cross-sectional, cohort (prospective and retrospective), and case-control studies that address periodontal disease in patients with Non-alcoholic Fatty Liver Disease, and aged ≥ 18 years. The search was without the restriction of language and publication time.</span></span> <!-->The search resulted in 954 articles. After applying the selection criteria, five cross-sectional studies remained. A metanalysis combined the study estimates of periodontal disease in NAFLD, by using the random effects. The Odds Ratio (1.91; 95% CI 1.21–3.02; P = 0.006) indicates that the chance of presenting Periodontal disease is 91% higher in individuals with NAFLD when compared with individuals without NAFLD. There are few studies with appropriate methodology to produce sound evidence about the causal relationship between the use of NAFLD and PD, however, studies support the association. So, dental staff must be aware of this association for better management of periodontal disease in patients with NAFLD.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arab Journal of Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1687197923000655","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease, comprising hepatic steatosis, and non-alcoholic steatohepatitis. Periodontal disease (PD) may be a risk factor for the evolution of liver cirrhosis. This study aimed to evaluate the association between NAFLD and PD.We searched in Pubmed, Scopus, Cochrane, and Lilacs databases with descriptors (Non-alcoholic Fatty Liver Disease OR (non-alcoholic AND Fatty Liver AND disease) OR Nonalcoholic Steatohepatitis) AND (Periodontal Disease OR Gingivitis OR Periodontitis) from January 2021 to September 2021. We selected, by the abstract, cross-sectional, cohort (prospective and retrospective), and case-control studies that address periodontal disease in patients with Non-alcoholic Fatty Liver Disease, and aged ≥ 18 years. The search was without the restriction of language and publication time. The search resulted in 954 articles. After applying the selection criteria, five cross-sectional studies remained. A metanalysis combined the study estimates of periodontal disease in NAFLD, by using the random effects. The Odds Ratio (1.91; 95% CI 1.21–3.02; P = 0.006) indicates that the chance of presenting Periodontal disease is 91% higher in individuals with NAFLD when compared with individuals without NAFLD. There are few studies with appropriate methodology to produce sound evidence about the causal relationship between the use of NAFLD and PD, however, studies support the association. So, dental staff must be aware of this association for better management of periodontal disease in patients with NAFLD.
非酒精性脂肪性肝病(NAFLD)是一种慢性肝病,包括肝脂肪变性和非酒精性脂肪性肝炎。牙周病(PD)可能是肝硬化发展的危险因素。本研究旨在评估NAFLD与PD之间的关系。我们从2021年1月至2021年9月在Pubmed、Scopus、Cochrane和Lilacs数据库中检索了描述词(非酒精性脂肪性肝病或(非酒精性和脂肪性肝病)或非酒精性脂肪性肝炎)和(牙周病或牙龈炎或牙周炎)。我们通过摘要选择了横断面、队列(前瞻性和回顾性)和病例对照研究,这些研究涉及年龄≥18岁的非酒精性脂肪性肝病患者的牙周病。检索不受语言和出版时间的限制。搜索结果是954篇文章。在应用选择标准后,还剩下5个横断面研究。一项荟萃分析结合了NAFLD中牙周病的研究估计,通过使用随机效应。优势比(1.91;95% ci 1.21-3.02;P = 0.006)表明NAFLD患者出现牙周病的几率比非NAFLD患者高91%。很少有研究采用适当的方法来提供关于使用NAFLD和PD之间因果关系的可靠证据,然而,研究支持这种联系。因此,牙科工作人员必须意识到这种关联,以便更好地管理NAFLD患者的牙周病。
期刊介绍:
Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.