Diabetes Mellitus and Acute Facial Palsy: A Nationwide Population-Based Study.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY Neuroepidemiology Pub Date : 2024-01-01 Epub Date: 2023-11-22 DOI:10.1159/000534760

Hee Won Seo, Soorack Ryu, Seung Hwan Lee, Jae Ho Chung

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引用次数: 0

Abstract

Introduction: Acute facial palsy, characterized by sudden hemifacial weakness, significantly impacts an individual's quality of life. Despite several predisposing factors identified for acute facial palsy, the specific relationship between diabetes mellitus (DM) and acute facial palsy has not been comprehensively explored in recent studies. The aim of the study was to assess the risk of acute facial palsy in patients with DM using a nationwide population sample cohort.

Methods: DM cohort and non-DM cohort were built using the Korean National Health Insurance Service-Sample Cohort which represents the entire population of the Republic of Korea from January 2002 to December 2019. The DM cohort comprised 92,872 patients with a record of medication and a diagnosis of DM. Individuals who had facial palsy before the diagnosis of DM were excluded. A comparison cohort comprised 1,012,021 individuals without DM matched sociodemographically in a 1:4 ratio. The incidence of Bell's palsy (BP) and Ramsay Hunt syndrome (RHS) were evaluated in both cohorts. The risk factors for acute facial palsy were also assessed.

Results: Among the 92,868 patients in the DM cohort, the incidence rate (IR) of BP and RHS were 31.42 (confidence interval [CI], 30.24-32.63) and 4.58 per 10,000 person-years (CI, 4.14-5.05), respectively. Among the 371,392 individuals in the non-DM cohort, the IR of BP was 22.11 per 10,000 person-years (CI, 21.62-22.59) and the IR of RHS was 2.85 per 10,000 person-years (CI, 2.68-3.02). IR ratios for BP and RHS were 1.42 (CI, 1.36-1.48) and 1.61 (CI, 1.43-1.80). In multivariate analysis, DM (hazard ratio [HR] 1.428), age (HR 1.008), and high comorbidity score (HR 1.051) were associated with increased risk of BP, and male (HR 0.803) and living in metropolis (HR 0.966) decreased the risk of BP. And DM (HR 1.615), high comorbidity score (HR 1.078), and living in metropolis (HR 1.201) were associated with increased risk for RHS.

Conclusion: This study suggests that patients with DM had an increased risk of acute facial palsy including BP and RHS.

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糖尿病和急性面瘫:一项基于全国人群的研究。

急性面瘫以突然的半面部无力为特征，严重影响患者的生活质量。尽管发现了几种诱发急性面瘫的因素，但近期研究尚未全面探讨糖尿病(DM)与急性面瘫的具体关系。该研究的目的是通过全国人口样本队列来评估糖尿病患者急性面瘫的风险。方法:采用2002年1月至2019年12月韩国国民健康保险服务样本队列，构建糖尿病队列和非糖尿病队列。DM队列包括92,872名有用药记录和诊断为DM的患者。在诊断为DM之前患有面瘫的个体被排除在外。比较队列包括1012021名没有糖尿病的人，在社会人口学上按1:4的比例匹配。评估两组患者贝尔麻痹(BP)和拉姆齐·亨特综合征(RHS)的发生率。急性面瘫的危险因素也进行了评估。结果:在DM队列的92,868例患者中，BP和RHS的发病率(IR)分别为31.42(置信区间[CI]， 30.24-32.63)和4.58(置信区间[CI]， 4.14-5.05) / 10,000人年。在371,392名非糖尿病患者中，BP的IR为22.11 / 10,000人-年(CI, 21.62-22.59)， RHS的IR为2.85 / 10,000人-年(CI, 2.68-3.02)。BP和RHS的IR比值分别为1.42 (CI, 1.36-1.48)和1.61 (CI, 1.43-1.80)。多因素分析中，糖尿病(危险比[HR] 1.428)、年龄(危险比[HR] 1.008)、合并症评分高(危险比[HR] 1.051)与BP风险增加相关，男性(危险比[HR] 0.803)和居住在大都市(危险比[HR] 0.966)降低BP风险。糖尿病(HR 1.615)、高合并症评分(HR 1.078)和居住在大都市(HR 1.201)与RHS风险增加相关。结论:本研究提示糖尿病患者发生包括BP和RHS在内的急性面瘫的风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

9.90

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.