Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case report

Q1 Nursing Technical Innovations and Patient Support in Radiation Oncology Pub Date : 2023-11-18 DOI:10.1016/j.tipsro.2023.100222

Takashi Saito , Motohiro Murakami , Taisuke Sumiya , Daisuke Kobayashi , Haruka Shirataki , Den Fujioka , Keiichiro Baba , Hiroya Itagaki , Yuri Tenjimbayashi , Toyomi Satoh , Hideyuki Sakurai

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Abstract

A female patient in her 50 s was found to have a 10-cm tumor resulting from locally advanced cervical cancer (LACC). Three-year relapse-free survival was achieved following a multimodal treatment strategy integrating chemoradiotherapy (CRT), regional hyperthermia (RHT), and interstitial brachytherapy (ISBT). Given the large size of the tumor, enhancement of the geometrical dose distribution was anticipated using ISBT. However, delivery of a sufficient dose to the high-risk clinical target volume was predicted to be challenging. Thus, RHT was incorporated to potentially augment the overall treatment effect. This unique combination of CRT, RHT and ISBT may be promising for management of large LACC and warrants further investigation.

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放化疗、局部热疗及间质性近距离放射治疗巨大局部晚期宫颈癌1例

一位50多岁的女性患者被发现有一个10厘米的肿瘤，由局部晚期宫颈癌(LACC)引起。通过综合放化疗(CRT)、局部热疗(RHT)和间质近距离放射治疗(ISBT)的多模式治疗策略，实现了三年无复发生存期。考虑到肿瘤的大尺寸，预期使用ISBT可以增强几何剂量分布。然而，预计向高风险临床靶体积递送足够剂量是具有挑战性的。因此，纳入RHT可能会增加整体治疗效果。CRT, RHT和ISBT的独特组合可能对大型LACC的治疗有希望，值得进一步研究。

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