Loss of B1 and marginal zone B cells during ovarian cancer

IF 3.7 4区 医学 Q2 CELL BIOLOGY Cellular immunology Pub Date : 2023-11-22 DOI:10.1016/j.cellimm.2023.104788
Jeffrey Maslanka , Gretel Torres , Jennifer Londregan , Naomi Goldman , Daniel Silberman , John Somerville, James E. Riggs
{"title":"Loss of B1 and marginal zone B cells during ovarian cancer","authors":"Jeffrey Maslanka ,&nbsp;Gretel Torres ,&nbsp;Jennifer Londregan ,&nbsp;Naomi Goldman ,&nbsp;Daniel Silberman ,&nbsp;John Somerville,&nbsp;James E. Riggs","doi":"10.1016/j.cellimm.2023.104788","DOIUrl":null,"url":null,"abstract":"<div><p><span>Recent advances in immunotherapy<span> have not addressed the challenge presented by ovarian cancer. Although the peritoneum is an “accessible” locus for this disease there has been limited characterization of the immunobiology<span> therein. We investigated the ID8-C57BL/6J ovarian cancer model and found marked depletion of B1 cells from the ascites of the peritoneal cavity. There was also selective loss of the B1 and </span></span></span>marginal zone B cell<span> subsets from the spleen. Immunity to antigens that activate these subsets validated their loss rather than relocation. A marked influx of myeloid-derived suppressor cells correlated with B cell subset depletion. These observations are discussed in the context of the housekeeping burden placed on innate B cells during ovarian cancer and to foster consideration of B cell biology in therapeutic strategies to address this challenge.</span></p></div>","PeriodicalId":9795,"journal":{"name":"Cellular immunology","volume":"395 ","pages":"Article 104788"},"PeriodicalIF":3.7000,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellular immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0008874923001272","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Recent advances in immunotherapy have not addressed the challenge presented by ovarian cancer. Although the peritoneum is an “accessible” locus for this disease there has been limited characterization of the immunobiology therein. We investigated the ID8-C57BL/6J ovarian cancer model and found marked depletion of B1 cells from the ascites of the peritoneal cavity. There was also selective loss of the B1 and marginal zone B cell subsets from the spleen. Immunity to antigens that activate these subsets validated their loss rather than relocation. A marked influx of myeloid-derived suppressor cells correlated with B cell subset depletion. These observations are discussed in the context of the housekeeping burden placed on innate B cells during ovarian cancer and to foster consideration of B cell biology in therapeutic strategies to address this challenge.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
卵巢癌期间B1和边缘区B细胞的缺失
免疫疗法的最新进展尚未解决卵巢癌带来的挑战。虽然腹膜是这种疾病的“可接近”的位点,但对其免疫生物学的描述有限。我们研究了ID8-C57BL/6J卵巢癌模型,发现腹腔腹水中B1细胞明显减少。脾脏的B1和边缘区B细胞亚群也有选择性丧失。对激活这些亚群的抗原的免疫证实了它们的丢失而不是重新定位。髓源性抑制细胞的显著内流与B细胞亚群耗竭相关。这些观察结果在卵巢癌期间对先天B细胞的家务负担的背景下进行了讨论,并促进了B细胞生物学在治疗策略中的考虑,以应对这一挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Cellular immunology
Cellular immunology 生物-免疫学
CiteScore
8.20
自引率
2.30%
发文量
102
审稿时长
30 days
期刊介绍: Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.
期刊最新文献
Immunomodulation by galectin-9: Distinct role in T cell populations, current therapeutic avenues and future potential. Ubiquitination and degradation of MHC-II by Tim-3 inhibits antiviral immunity Gastrodenol suppresses NLRP3/GSDMD mediated pyroptosis and ameliorates inflammatory diseases Complement system component 3 deficiency modulates the phenotypic profile of murine macrophages Drug screening identifies pyrrolidinedithiocarbamate ammonium ameliorating DSS-induced mouse ulcerative colitis via suppressing Th17 differentiation
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1