Loss of B1 and marginal zone B cells during ovarian cancer

IF 3.7 4区 医学 Q2 CELL BIOLOGY Cellular immunology Pub Date : 2023-11-22 DOI:10.1016/j.cellimm.2023.104788
Jeffrey Maslanka , Gretel Torres , Jennifer Londregan , Naomi Goldman , Daniel Silberman , John Somerville, James E. Riggs
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Abstract

Recent advances in immunotherapy have not addressed the challenge presented by ovarian cancer. Although the peritoneum is an “accessible” locus for this disease there has been limited characterization of the immunobiology therein. We investigated the ID8-C57BL/6J ovarian cancer model and found marked depletion of B1 cells from the ascites of the peritoneal cavity. There was also selective loss of the B1 and marginal zone B cell subsets from the spleen. Immunity to antigens that activate these subsets validated their loss rather than relocation. A marked influx of myeloid-derived suppressor cells correlated with B cell subset depletion. These observations are discussed in the context of the housekeeping burden placed on innate B cells during ovarian cancer and to foster consideration of B cell biology in therapeutic strategies to address this challenge.

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卵巢癌期间B1和边缘区B细胞的缺失
免疫疗法的最新进展尚未解决卵巢癌带来的挑战。虽然腹膜是这种疾病的“可接近”的位点,但对其免疫生物学的描述有限。我们研究了ID8-C57BL/6J卵巢癌模型,发现腹腔腹水中B1细胞明显减少。脾脏的B1和边缘区B细胞亚群也有选择性丧失。对激活这些亚群的抗原的免疫证实了它们的丢失而不是重新定位。髓源性抑制细胞的显著内流与B细胞亚群耗竭相关。这些观察结果在卵巢癌期间对先天B细胞的家务负担的背景下进行了讨论,并促进了B细胞生物学在治疗策略中的考虑,以应对这一挑战。
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来源期刊
Cellular immunology
Cellular immunology 生物-免疫学
CiteScore
8.20
自引率
2.30%
发文量
102
审稿时长
30 days
期刊介绍: Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.
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