Cover Picture: Development for a new 5-lipoxygenase inhibitors of N-((6-(substituted-amino)-2-methyl-2H-chromen-2-yl)methyl)-N-methyl benzenesulfonamide derivatives (BKCS 11/2023) Young-Chang Kim, Aizhan Abdildinova, Ye Jin Shin, Dong Kyun Han, Jong Yeon Hwang, Hyae Gyeong Cheon, Young-Dae Gong
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Abstract
The cover picture illustrates the design process of a new 5-LO inhibitor through molecular hybridization. The highlighted portions in each chemical structure represent the regions where structural fusion is applied, and the sparks depict the process of fusion. The target compound acts on the 5-LO protein in mouse, relieving the ear edema. The drugs indicated by the prohibition sign in the bottom right corner are steroid-based drug and a 5-LO target drug called Zeiluton, both have toxicity issues. More details are available in the article by Young-Chang Kim, Aizhan Abdildinova, Ye Jin Shin, Dong Kyun Han, Jong Yeon Hwang, Hyae Gyeong Cheon, Young-Dae Gong.
期刊介绍：
The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.
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