Current Status and Progress in Stem Cell Therapy for Intracerebral Hemorrhage.

IF 4.3 2区医学 Q1 CLINICAL NEUROLOGY Translational Stroke Research Pub Date : 2025-04-01 Epub Date: 2023-11-25 DOI:10.1007/s12975-023-01216-7

Ning Ding, Ran Luo, Qian Zhang, Huanhuan Li, Shuixian Zhang, Huanran Chen, Rong Hu

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Abstract

Intracerebral hemorrhage is a highly prevalent and prognostically poor disease, imposing immeasurable harm on human life and health. However, the treatment options for intracerebral hemorrhage are severely limited, particularly in terms of improving the microenvironment of the lesion, promoting neuronal cell survival, and enhancing neural function. This review comprehensively discussed the application of stem cell therapy for intracerebral hemorrhage, providing a systematic summary of its developmental history, types of transplants, transplantation routes, and transplantation timing. Moreover, this review presented the latest research progress in enhancing the efficacy of stem cell transplantation, including pretransplantation preconditioning, genetic modification, combined therapy, and other diverse strategies. Furthermore, this review pioneeringly elaborated on the barriers to clinical translation for stem cell therapy. These discussions were of significant importance for promoting stem cell therapy for intracerebral hemorrhage, facilitating its clinical translation, and improving patient prognosis.

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脑出血干细胞治疗的现状与进展。

脑出血是一种高发、预后差的疾病，对人类生命健康造成不可估量的危害。然而，脑出血的治疗选择严重有限，特别是在改善病变微环境、促进神经元细胞存活和增强神经功能方面。本文就脑出血干细胞治疗的发展历史、移植类型、移植途径和移植时机等方面进行了系统的综述。此外，本文综述了提高干细胞移植疗效的最新研究进展，包括移植前预处理、基因改造、联合治疗等多种策略。此外，这篇综述开创性地阐述了干细胞治疗临床转化的障碍。这些讨论对于促进脑出血干细胞治疗，促进其临床转化，改善患者预后具有重要意义。

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来源期刊

Translational Stroke Research CLINICAL NEUROLOGY-NEUROSCIENCES

CiteScore

13.80

自引率

4.30%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Translational Stroke Research covers basic, translational, and clinical studies. The Journal emphasizes novel approaches to help both to understand clinical phenomenon through basic science tools, and to translate basic science discoveries into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma. Translational Stroke Research focuses on translational research and is relevant to both basic scientists and physicians, including but not restricted to neuroscientists, vascular biologists, neurologists, neuroimagers, and neurosurgeons.