Non-conducting functions of potassium channels in cancer and neurological disease.

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2023-01-01 Epub Date: 2023-09-22 DOI:10.1016/bs.ctm.2023.09.007
Federico Sesti, Alessandro Bortolami, Elena Forzisi Kathera-Ibarra
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Abstract

Cancer and neurodegenerative disease, albeit fundamental differences, share some common pathogenic mechanisms. Accordingly, both conditions are associated with aberrant cell proliferation and migration. Here, we review the causative role played by potassium (K+) channels, a fundamental class of proteins, in cancer and neurodegenerative disease. The concept that emerges from the review of the literature is that K+ channels can promote the development and progression of cancerous and neurodegenerative pathologies by dysregulating cell proliferation and migration. K+ channels appear to control these cellular functions in ways that not necessarily depend on their conducting properties and that involve the ability to directly or indirectly engage growth and survival signaling pathways. As cancer and neurodegenerative disease represent global health concerns, identifying commonalities may help understand the molecular basis for those devastating conditions and may facilitate the design of new drugs or the repurposing of existing drugs.

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钾通道在癌症和神经系统疾病中的非传导功能。
癌症和神经退行性疾病,尽管有根本的区别,但有一些共同的致病机制。因此,这两种情况都与异常细胞增殖和迁移有关。在这里,我们回顾了钾离子通道在癌症和神经退行性疾病中的致病作用,钾离子通道是一类基本的蛋白质。从文献综述中出现的概念是,K+通道可以通过失调细胞增殖和迁移来促进癌症和神经退行性病变的发生和进展。K+通道似乎以不一定依赖于其传导特性的方式控制这些细胞功能,并涉及直接或间接参与生长和生存信号通路的能力。由于癌症和神经退行性疾病代表着全球健康问题,确定共性可能有助于了解这些毁灭性疾病的分子基础,并可能促进新药的设计或现有药物的重新利用。
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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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