The role of ion channels in the relationship between the immune system and cancer.

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2023-01-01 Epub Date: 2023-09-22 DOI:10.1016/bs.ctm.2023.09.001
Mumin Alper Erdogan, D'Amora Ugo, Fasolino Ines
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Abstract

The immune system is capable of identifying and eliminating cancer, a complicated illness marked by unchecked cellular proliferation. The significance of ion channels in the complex interaction between the immune system and cancer has been clarified by recent studies. Ion channels, which are proteins that control ion flow across cell membranes, have variety of physiological purposes, such as regulating immune cell activity and tumor development. Immune cell surfaces contain ion channels, which have been identified to control immune cell activation, motility, and effector activities. The regulation of immune responses against cancer cells has been linked to a number of ion channels, including potassium, calcium, and chloride channels. As an example, potassium channels are essential for regulating T cell activation and proliferation, which are vital for anti-tumor immunity. Calcium channels play a crucial role when immune cells produce cytotoxic chemicals in order to eliminate cancer cells. Chloride channels also affect immune cell infiltration and invasion into malignancies. Additionally, tumor cells' own expressed ion channels have an impact on their behavior and in the interaction with the immune system. The proliferation, resistance to apoptosis, and immune evasion of cancer cells may all be impacted by changes in ion channel expression and function. Ion channels may also affect the tumor microenvironment by controlling angiogenesis, inflammatory responses, and immune cell infiltration. Ion channel function in the interaction between the immune system and cancer has important implications for cancer treatment. A possible method to improve anti-tumor immune responses and stop tumor development is to target certain ion channels. Small compounds and antibodies are among the ion channel modulators under investigation as possible immunotherapeutics. The complex interaction between ion channels, the immune system, and cancer highlights the significance of these channels for tumor immunity. The development of novel therapeutic strategies for the treatment of cancer will be made possible by unraveling the processes by which ion channels control immune responses and tumor activity. Hence, the main driving idea of the present chapter is trying to understand the possible function of ion channels in the complex crosstalk between cancer and immunoresponse. To this aim, after giving a brief journey of ion channels throughout the history, a classification of the main ion channels involved in cancer disease will be discussed. Finally, the last paragraph will focus on more recently advancements in the use of biomaterials as therapeutic strategy for cancer treatment. The hope is that future research will take advantage of the promising combination of ion channels, immunomodulation and biomaterials filed to provide better solutions in the treatment of cancer disease.

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离子通道在免疫系统和癌症关系中的作用。
免疫系统能够识别和消除癌症,这是一种复杂的疾病,其特征是不受控制的细胞增殖。离子通道在免疫系统与肿瘤复杂相互作用中的重要作用已被近年来的研究所阐明。离子通道是一种控制离子在细胞膜上流动的蛋白质,具有多种生理目的,如调节免疫细胞活性和肿瘤的发展。免疫细胞表面含有离子通道,已被确定控制免疫细胞的激活、运动和效应活性。针对癌细胞的免疫反应的调节与许多离子通道有关,包括钾、钙和氯离子通道。例如,钾通道在调节T细胞的活化和增殖中是必不可少的,而T细胞的活化和增殖对抗肿瘤免疫至关重要。当免疫细胞产生细胞毒性化学物质以消灭癌细胞时,钙通道起着至关重要的作用。氯离子通道也影响免疫细胞的浸润和对恶性肿瘤的侵袭。此外,肿瘤细胞自身表达的离子通道对其行为和与免疫系统的相互作用也有影响。肿瘤细胞的增殖、抗凋亡和免疫逃逸都可能受到离子通道表达和功能变化的影响。离子通道也可能通过控制血管生成、炎症反应和免疫细胞浸润来影响肿瘤微环境。离子通道在免疫系统与肿瘤相互作用中的作用对癌症治疗具有重要意义。一种可能提高抗肿瘤免疫反应和阻止肿瘤发展的方法是靶向某些离子通道。小化合物和抗体是正在研究的离子通道调节剂中可能的免疫治疗药物。离子通道、免疫系统和癌症之间复杂的相互作用凸显了这些通道对肿瘤免疫的重要性。通过揭示离子通道控制免疫反应和肿瘤活性的过程,癌症治疗新治疗策略的发展将成为可能。因此,本章的主要驱动思想是试图理解离子通道在癌症和免疫反应之间复杂的串扰中的可能功能。为此,在简要介绍了离子通道的历史之后,我们将讨论与癌症疾病有关的主要离子通道的分类。最后,最后一段将重点介绍生物材料作为癌症治疗策略的最新进展。希望未来的研究将利用离子通道,免疫调节和生物材料领域的有前途的组合,为癌症疾病的治疗提供更好的解决方案。
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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
期刊最新文献
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