Ancestral Information Analysis of Chinese Korean Ethnic Group via a Novel Multiplex DIP System.

IF 2.1 3区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Molecular Evolution Pub Date : 2023-12-01 Epub Date: 2023-11-25 DOI:10.1007/s00239-023-10143-y

Meiming Cai, Shuanglin Li, Xingru Zhang, Weibing Xie, Jianfeng Shi, Xi Yuan, Jun Yao, Bofeng Zhu

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Abstract

Deletion/insertion polymorphism (DIP) is one of the more promising genetic markers in the field of forensic genetics for personal identification and biogeographic ancestry inference. In this research, we used an in-house developed ancestry-informative marker-DIP system, including 56 autosomal diallelic DIPs, three Y-chromosomal DIPs, and an Amelogenin gene, to analyze the genetic polymorphism and ancestral composition of the Chinese Korean group, as well as to explore its genetic relationships with the 26 reference populations. The results showed that this novel panel exhibited high genetic polymorphism in the studied Korean group and could be effectively applied for forensic individual identification in the Korean group. In addition, the results of multiple population genetic analyses indicated that the ancestral component of the Korean group was dominated by northern East Asia. Moreover, the Korean group was more closely related to the East Asian populations, especially to the Japanese population in Tokyo. This study enriched the genetic data of the Korean ethnic group in China and provided information on the ancestry of the Korean group from the perspective of population genetics.

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基于新型多路DIP系统的中国朝鲜族祖先信息分析

缺失/插入多态性(DIP)是法医遗传学领域中最有前途的遗传标记之一，可用于个人鉴定和生物地理祖先推断。本研究采用自主开发的遗传信息标记dip系统，包括56个常染色体双等位基因dip、3个y染色体dip和1个淀粉原蛋白基因，分析了中国朝鲜族群体的遗传多态性和祖先组成，并探讨了其与26个参考群体的遗传关系。结果表明，该新面板在研究的韩国群体中具有较高的遗传多态性，可以有效地用于韩国群体的法医个体鉴定。此外，多种群遗传分析结果表明，韩国群体的祖先成分主要来自东亚北部。此外，韩国人与东亚人，尤其是东京的日本人关系更密切。本研究丰富了中国朝鲜族的遗传资料，从群体遗传学的角度提供了朝鲜族祖先的信息。

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来源期刊

Journal of Molecular Evolution 生物-进化生物学

CiteScore

5.50

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： Journal of Molecular Evolution covers experimental, computational, and theoretical work aimed at deciphering features of molecular evolution and the processes bearing on these features, from the initial formation of macromolecular systems through their evolution at the molecular level, the co-evolution of their functions in cellular and organismal systems, and their influence on organismal adaptation, speciation, and ecology. Topics addressed include the evolution of informational macromolecules and their relation to more complex levels of biological organization, including populations and taxa, as well as the molecular basis for the evolution of ecological interactions of species and the use of molecular data to infer fundamental processes in evolutionary ecology. This coverage accommodates such subfields as new genome sequences, comparative structural and functional genomics, population genetics, the molecular evolution of development, the evolution of gene regulation and gene interaction networks, and in vitro evolution of DNA and RNA, molecular evolutionary ecology, and the development of methods and theory that enable molecular evolutionary inference, including but not limited to, phylogenetic methods.