Clinical Studies on Topical Curcumin.

IF 2.8 4区医学 Q2 DERMATOLOGY Skin Pharmacology and Physiology Pub Date : 2023-01-01 Epub Date: 2023-11-26 DOI:10.1159/000535100

Ritamaria Di Lorenzo, Federica Forgione, Antonietta Bernardi, Antonia Sacchi, Sonia Laneri, Giovanni Greco

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Abstract

Background: Curcumin is a polyphenolic compound present in turmeric (Curcuma longa). Curcumin, turmeric powder, and extracts are widely used in traditional Indian medicine and are active ingredients of dietary supplements and cosmeceutical products. The pharmacological properties of curcumin/turmeric as well as the studies performed in vitro, in animal models, and in volunteers have been the objects of a vast literature. Most of the clinical studies report on the effects of curcumin/turmeric administered orally, while only a few describe its topical applications.

Summary: This review focuses on clinical studies in which curcumin/turmeric was applied topically to treat various skin conditions based on its antioxidant, anti-inflammatory, and antimicrobial properties.

Key messages: The clinical studies employing curcumin/turmeric as the only active ingredient allow us to appreciate its therapeutic potential without confounding contributions coming from additional pharmacologically active substances present in the same formulation. Curcumin/turmeric was regarded as an attractive alternative to conventional drugs, such as corticosteroids and antibiotics, thanks to its characteristics of a safe and well-tolerated natural substance.

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姜黄素作为外用药物的临床研究。

背景:姜黄素是存在于姜黄中的一种多酚类化合物。姜黄素、姜黄粉和提取物在印度传统医药中广泛使用，是膳食补充剂和药妆产品的有效成分。姜黄素/姜黄的药理学特性以及在体外、动物模型和志愿者中进行的评估其有效性的研究已经成为大量文献的对象。大多数临床研究报告了姜黄素/姜黄口服的效果，而只有少数描述其局部应用。摘要:本文综述了姜黄素/姜黄基于其抗氧化、抗炎和抗菌特性被局部应用于治疗各种皮肤状况的临床研究。关键信息:使用姜黄素/姜黄作为唯一活性成分的临床研究使我们能够欣赏其治疗潜力，而不会混淆来自同一配方中存在的其他药理活性物质的贡献。由于姜黄素/姜黄是一种安全且耐受性良好的天然物质，因此被认为是皮质类固醇和抗生素等传统药物的一种有吸引力的替代品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skin Pharmacology and Physiology 医学-皮肤病学

CiteScore

5.20

自引率

7.40%

发文量

审稿时长

>12 weeks

期刊介绍： In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.

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