Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia.

IF 1.4 4区医学 Q3 CLINICAL NEUROLOGY Alzheimer Disease & Associated Disorders Pub Date : 2023-10-01 Epub Date: 2023-11-28 DOI:10.1097/WAD.0000000000000585

Rachel Membreno, Kelsey R Thomas, Amanda T Calcetas, Lauren Edwards, Maria Bordyug, Maya Showell, Morgan Stanfill, Einat K Brenner, Kayla S Walker, Lindsay J Rotblatt, Adam M Brickman, Emily C Edmonds, Katherine J Bangen

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Abstract

Introduction: White matter hyperintensities (WMHs) are magnetic resonance imaging markers of small vessel cerebrovascular disease that are associated with cognitive decline and clinical Alzheimer disease. Previous studies have often focused on global or total WMH; less is known about associations of regional WMHs and cognitive abilities among older adults without dementia.

Methods: A total of 610 older adults with normal cognition (n=302) or mild cognitive impairment (n=308) from the Alzheimer's Disease Neuroimaging Initiative underwent neuropsychological testing and magnetic resonance imaging. Linear regression models examined associations between regional WMH volumes and cognition, adjusting for age, sex, education, apolipoprotein E ε4 allele frequency, and pulse pressure.

Results: Among all participants, greater regional WMH volume in all lobes was associated with poorer performance on memory and speed/executive functioning. Among participants with normal cognition, greater temporal and occipital WMH volumes were associated with poorer memory, whereas no regional WMH volumes were associated with speed/executive function.

Discussion: Results show that greater regional WMH volume relates to poorer cognitive functioning-even among those with normal cognition. Together with results from previous studies, our findings raise the possibility that WMH may be a useful therapeutic target and/or important effect modifier in treatment or prevention dementia trials.

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区域白质高强度与无痴呆老年人的特定认知能力有关。

简介:白质高强度(WMHs)是小血管脑血管疾病的磁共振成像标志物，与认知能力下降和临床阿尔茨海默病有关。以前的研究往往集中在全球或全部的WMH上;对于区域性脑卒中与无痴呆老年人认知能力之间的关系，我们所知较少。方法:来自阿尔茨海默病神经影像学倡议的610名认知正常(n=302)或轻度认知障碍(n=308)的老年人接受了神经心理测试和磁共振成像。线性回归模型检验了区域WMH量与认知之间的关系，调整了年龄、性别、教育程度、载脂蛋白ε4等位基因频率和脉压。结果:在所有参与者中，所有脑叶的地区性脑mh体积越大，记忆力和速度/执行功能的表现就越差。在认知正常的参与者中，颞部和枕部脑前皮层体积较大与较差的记忆力有关，而脑后皮层区域体积与速度/执行功能无关。讨论:研究结果表明，地区性脑mh体积越大，认知功能越差——即使在认知正常的人群中也是如此。结合以往的研究结果，我们的发现提出了一种可能性，即WMH可能是治疗或预防痴呆试验中有用的治疗靶点和/或重要的效果调节剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.