Vestibular contribution to spatial orientation and navigation.

IF 4.1 2区医学 Q1 CLINICAL NEUROLOGY Current Opinion in Neurology Pub Date : 2024-02-01 Epub Date: 2023-11-27 DOI:10.1097/WCO.0000000000001230

Andreas Zwergal, Denis Grabova, Florian Schöberl

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Abstract

Purpose of review: The vestibular system provides three-dimensional idiothetic cues for updating of one's position in space during head and body movement. Ascending vestibular signals reach entorhinal and hippocampal networks via head-direction pathways, where they converge with multisensory information to tune the place and grid cell code.

Recent findings: Animal models have provided insight to neurobiological consequences of vestibular lesions for cerebral networks controlling spatial cognition. Multimodal cerebral imaging combined with behavioural testing of spatial orientation and navigation performance as well as strategy in the last years helped to decipher vestibular-cognitive interactions also in humans.

Summary: This review will update the current knowledge on the anatomical and cellular basis of vestibular contributions to spatial orientation and navigation from a translational perspective (animal and human studies), delineate the behavioural and functional consequences of different vestibular pathologies on these cognitive domains, and will lastly speculate on a potential role of vestibular dysfunction for cognitive aging and impeding cognitive impairment in analogy to the well known effects of hearing loss.

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前庭对空间定位和导航的贡献。

回顾目的:前庭系统提供三维独特的线索，更新一个人的头部和身体的空间运动的位置。上行前庭信号通过头向通路到达内嗅和海马体网络，在那里它们与多感觉信息汇聚以调整位置和网格细胞代码。最近的发现:动物模型提供了前庭病变对控制空间认知的大脑网络的神经生物学后果的见解。近年来，多模态脑成像与空间定向和导航性能以及策略的行为测试相结合，也有助于破译人类前庭-认知相互作用。简介:这篇综述将从翻译的角度(动物和人类研究)更新前庭对空间定向和导航的解剖学和细胞基础的现有知识，描述不同的前庭病理对这些认知领域的行为和功能后果。最后，我们将推测前庭功能障碍在认知衰老和认知障碍方面的潜在作用，就像众所周知的听力损失一样。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurology 医学-临床神经学

CiteScore

8.60

自引率

0.00%

发文量

174

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Neurology is a highly regarded journal offering insightful editorials and on-the-mark invited reviews; covering key subjects such as cerebrovascular disease, developmental disorders, neuroimaging and demyelinating diseases. Published bimonthly, each issue of Current Opinion in Neurology introduces world renowned guest editors and internationally recognized academics within the neurology field, delivering a widespread selection of expert assessments on the latest developments from the most recent literature.