Deeper insight into ferroptosis: association with Alzheimer's, Parkinson's disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis.

IF 5.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI:10.1080/13510002.2023.2269331
Virendra Kumar Yadav, Nisha Choudhary, Amel Gacem, Rakesh Kumar Verma, Mohd Abul Hasan, Mohammad Tarique Imam, Ziyad Saeed Almalki, Krishna Kumar Yadav, Hyun-Kyung Park, Tathagata Ghosh, Pankaj Kumar, Ashish Patel, Haresh Kalasariya, Byong-Hun Jeon, Hassan Ali AlMubarak
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Abstract

Ferroptosis is an emerging and novel type of iron-dependent programmed cell death which is mainly caused by the excessive deposition of free intracellular iron in the brain cells. This deposited free iron exerts a ferroptosis pathway, resulting in lipid peroxidation (LiPr). There are mainly three ferroptosis pathways viz. iron metabolism-mediated cysteine/glutamate, and LiPr-mediated. Iron is required by the brain as a redox metal for several physiological activities. Due to the iron homeostasis balance disruption, the brain gets adversely affected which further causes neurodegenerative diseases (NDDs) like Parkinson's and Alzheimer's disease, strokes, and brain tumors like glioblastoma (GBS), and glioma. Nanotechnology has played an important role in the prevention and treatment of these NDDs. A synergistic effect of nanomaterials and ferroptosis could prove to be an effective and efficient approach in the field of nanomedicine. In the current review, the authors have highlighted all the latest research in the field of ferroptosis, specifically emphasizing on the role of major molecular key players and various mechanisms involved in the ferroptosis pathway. Moreover, here the authors have also addressed the correlation of ferroptosis with the pathophysiology of NDDs and theragnostic effect of ferroptosis and nanomaterials for the prevention and treatment of NDDs.

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更深入地了解铁下垂:与阿尔茨海默病、帕金森病和脑肿瘤的关系,以及纳米材料诱导铁下垂的可能治疗方法。
铁凋亡是一种新型的铁依赖性程序性细胞死亡,主要是由脑细胞内游离铁的过度沉积引起的。这种沉积的游离铁发挥铁下垂途径,导致脂质过氧化(LiPr)。铁下垂途径主要有铁代谢介导的半胱氨酸/谷氨酸和脂质酶介导的三种。铁作为一种氧化还原金属是大脑进行多种生理活动所必需的。由于铁体内平衡的破坏,大脑受到不利影响,进一步导致神经退行性疾病(ndd),如帕金森病和阿尔茨海默病,中风,脑肿瘤,如胶质母细胞瘤(GBS)和胶质瘤。纳米技术在这些ndd的预防和治疗中发挥了重要作用。纳米材料与铁下垂的协同效应可能是纳米医学领域的一种有效途径。在本文中,作者对铁下垂领域的最新研究进行了综述,重点介绍了铁下垂途径中主要关键分子的作用和各种机制。此外,作者还讨论了铁下垂与ndd的病理生理关系以及铁下垂和纳米材料在ndd预防和治疗中的诊断作用。
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来源期刊
Redox Report
Redox Report 生物-生化与分子生物学
CiteScore
6.10
自引率
0.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.
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