Roles of the CCR4-Not complex in translation and dynamics of co-translation events.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-11-27 DOI:10.1002/wrna.1827
Martine A Collart, Léna Audebert, Martin Bushell
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Abstract

The Ccr4-Not complex is a global regulator of mRNA metabolism in eukaryotic cells that is most well-known to repress gene expression. Delivery of the complex to mRNAs through a multitude of distinct mechanisms accelerates their decay, yet Ccr4-Not also plays an important role in co-translational processes, such as co-translational association of proteins and delivery of translating mRNAs to organelles. The recent structure of Not5 interacting with the translated ribosome has brought to light that embedded information within the codon sequence can be monitored by recruitment of the Ccr4-Not complex to elongating ribosomes. Thereby, the Ccr4-Not complex is empowered with regulatory decisions determining the fate of proteins being synthesized and their encoding mRNAs. This review will focus on the roles of the complex in translation and dynamics of co-translation events. This article is categorized under: Translation > Mechanisms Translation > Regulation.

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ccr4 -不复杂在翻译中的作用及共译事件的动态。
Ccr4-Not复合体是真核细胞中mRNA代谢的全局调节剂,最著名的是抑制基因表达。Ccr4-Not复合物通过多种不同的机制传递给mrna,加速了它们的衰变,但Ccr4-Not在共翻译过程中也起着重要作用,例如蛋白质的共翻译结合和翻译mrna向细胞器的传递。最近的Not5与翻译核糖体相互作用的结构揭示了密码子序列内嵌入的信息可以通过招募ccr4 -不复杂的延长核糖体来监测。因此,Ccr4-Not复合体被赋予了决定被合成蛋白质及其编码mrna命运的调控决策。本文将重点讨论复合体在翻译中的作用和共译事件的动态。本文分类为:翻译>翻译机制>规则。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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