Genetics of metabolic traits in Greenlanders.

IF 1 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Danish medical journal Pub Date : 2023-11-16
Anne Cathrine Baun Thuesen, Mette K Andersen, Torben Hansen
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Abstract

The history of the Greenlandic population has contributed to a unique genetic composition in which high-impact and often novel genetic variants segregate at a high frequency. As a result, research in smaller populations like the Greenlandic has the potential to reveal genetic variation and associations that are not present or discoverable in other populations. In this review, we provide a summary of our research in Greenlanders and our findings of genetic variants with high impact on metabolic health, and outline the implications that this research has for the equitable distribution of genomic precision medicine.

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格陵兰人代谢性状的遗传学。
格陵兰人口的历史促成了一种独特的遗传组成,在这种遗传组成中,高影响和往往新颖的遗传变异以高频率分离。因此,在像格陵兰岛这样较小的人群中进行的研究有可能揭示在其他人群中不存在或未被发现的遗传变异和关联。在这篇综述中,我们总结了我们在格陵兰岛的研究和我们对代谢健康有高影响的遗传变异的发现,并概述了这项研究对基因组精准医学公平分配的影响。
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来源期刊
Danish medical journal
Danish medical journal MEDICINE, GENERAL & INTERNAL-
CiteScore
2.30
自引率
6.20%
发文量
78
审稿时长
3-8 weeks
期刊介绍: The Danish Medical Journal (DMJ) is a general medical journal. The journal publish original research in English – conducted in or in relation to the Danish health-care system. When writing for the Danish Medical Journal please remember target audience which is the general reader. This means that the research area should be relevant to many readers and the paper should be presented in a way that most readers will understand the content. DMJ will publish the following articles: • Original articles • Protocol articles from large randomized clinical trials • Systematic reviews and meta-analyses • PhD theses from Danish faculties of health sciences • DMSc theses from Danish faculties of health sciences.
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