The Role of Exosomes from Mesenchymal Stem Cells in Spinal Cord Injury: A Systematic Review.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-08-30 Epub Date: 2023-11-29 DOI:10.15283/ijsc23092

Haoyu Wang, Chunxia Zhao, Qingqing Rong, Jinghe Cao, Hongyi Chen, Ruolin Li, Bin Zhang, Peng Xu

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Abstract

Spinal cord injury (SCI) is a serious nervous system disease that usually leads to the impairment of the motor, sensory, and autonomic nervous functions of the spinal cord, and it places a heavy burden on families and healthcare systems every year. Due to the complex pathophysiological mechanism of SCI and the poor ability of neurons to regenerate, the current treatment scheme has very limited effects on the recovery of spinal cord function. In addition, due to their unique advantages, exosomes can be used as carriers for cargo transport. In recent years, some studies have confirmed that treatment with mesenchymal stem cells (MSCs) can promote the recovery of SCI nerve function. The therapeutic effect of MSCs is mainly related to exosomes secreted by MSCs, and exosomes may have great potential in SCI therapy. In this review, we summarized the repair mechanism of mesenchymal stem cells-derived exosomes (MSCs-Exos) in SCI treatment and discussed the microRNAs related to SCI treatment based on MSCs-Exos and their mechanism of action, which is helpful to further understand the role of exosomes in SCI.

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间充质干细胞外泌体在脊髓损伤中的作用:系统综述。

脊髓损伤(SCI)是一种严重的神经系统疾病，通常导致脊髓的运动、感觉和自主神经功能受损，每年都给家庭和医疗系统带来沉重的负担。由于脊髓损伤的病理生理机制复杂，神经元再生能力差，目前的治疗方案对脊髓功能的恢复效果非常有限。此外，外泌体由于其独特的优势，可以作为货物运输的载体。近年来，一些研究证实用间充质干细胞(mesenchymal stem cells, MSCs)治疗可以促进脊髓损伤神经功能的恢复。MSCs的治疗效果主要与MSCs分泌的外泌体有关，外泌体在SCI治疗中可能具有很大的潜力。本文综述了间充质干细胞衍生外泌体(MSCs-Exos)在SCI治疗中的修复机制，并讨论了基于MSCs-Exos的SCI治疗相关microrna及其作用机制，有助于进一步了解外泌体在SCI中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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