Dry Powder Inhalers: From Bench to Bedside.

IF 2 4区 医学 Q3 RESPIRATORY SYSTEM Journal of Aerosol Medicine and Pulmonary Drug Delivery Pub Date : 2023-12-01 Epub Date: 2023-11-28 DOI:10.1089/jamp.2023.29103.hc
Henry Chrystyn, Wahida Azouz, Walid Tarsin
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Abstract

Dry powder inhalers (DPIs) are now widely prescribed and preferred by the majority of patients. These devices have many advantages over the traditional pressurized metered-dose inhaler (pMDI) but they do have disadvantages. The characteristics of the dose emitted from a DPI are affected by the inhalation manoeuvre used by a patient. Each patient is different and the severity of their lung disease varies from mild to very severe. This affects how they use an inhaler and so determines the type of dose they inhale. An understanding of the pharmaceutical science related to DPIs is important to appreciate the relevance of how patients inhale through these devices. Also, each type of DPI has its unique dose preparation routine, and thus it is essential to follow these recommended steps because errors at this stage may result in no dose being inhaled. All issues related to the inhalation manoeuvre and dose preparation are addressed in this chapter. The importance of the inhalation technique is highlighted with a realization of inhale technique training and checking. During routine patient management, devices should not be switched nor doses increased unless the patient has demonstrated that they can and do use their DPI.

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干粉吸入器:从工作台到床边。
干粉吸入器(dpi)现在被广泛处方和首选的大多数患者。这些装置比传统的加压计量吸入器(pMDI)有许多优点,但它们也有缺点。从DPI发出的剂量的特性受患者使用的吸入操作的影响。每个病人都不同,他们的肺部疾病的严重程度从轻微到非常严重不等。这会影响他们使用吸入器的方式,从而决定他们吸入的剂量类型。了解与dpi相关的制药科学对于理解患者如何通过这些装置吸入的相关性是很重要的。此外,每种DPI都有其独特的剂量制备程序,因此必须遵循这些建议的步骤,因为这一阶段的错误可能导致没有剂量被吸入。与吸入操作和剂量制备有关的所有问题都在本章中讨论。通过对吸气技术训练和检查的实现,强调了吸气技术的重要性。在患者的常规管理中,除非患者证明他们能够并且确实使用DPI,否则不应切换设备或增加剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.70
自引率
2.90%
发文量
34
审稿时长
>12 weeks
期刊介绍: Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.
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