Liver T1 and T2 mapping in a large cohort of healthy subjects: normal ranges and correlation with age and sex.

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2024-02-01 Epub Date: 2023-11-29 DOI:10.1007/s10334-023-01135-6
Antonella Meloni, Aldo Carnevale, Paolo Gaio, Vincenzo Positano, Cristina Passantino, Alessia Pepe, Andrea Barison, Giancarlo Todiere, Chrysanthos Grigoratos, Giovanni Novani, Laura Pistoia, Melchiore Giganti, Filippo Cademartiri, Alberto Cossu
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Abstract

Objective: We established normal ranges for native T1 and T2 values in the human liver using a 1.5 T whole-body imager (General Electric) and we evaluated their variation across hepatic segments and their association with age and sex.

Materials and methods: One-hundred healthy volunteers aged 20-70 years (50% females) underwent MRI. Modified Look-Locker inversion recovery and multi-echo fast-spin-echo sequences were used to measure hepatic native global and segmental T1 and T2 values, respectively.

Results: T1 and T2 values exhibited good intra- and inter-observer reproducibility (coefficient of variation < 5%). T1 value over segment 4 was significantly lower than the T1 values over segments 2 and 3 (p < 0.0001). No significant regional T2 variability was detected. Segmental and global T1 values were not associated with age or sex. Global T2 values were independent from age but were significantly lower in males than in females. The lower and upper limits of normal for global T1 values were, respectively, 442 ms and 705 ms. The normal range for global T2 values was 35 ms-54 ms in males and 39 ms-54 ms in females.

Discussion: Liver T1 and T2 mapping is feasible and reproducible and the provided normal ranges may help to establish diagnosis and progression of various liver diseases.

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一大群健康受试者的肝脏T1和T2定位:正常范围及与年龄和性别的相关性
目的:我们使用1.5 T全身显像仪(通用电气)建立了人肝脏天然T1和T2值的正常范围,并评估了它们在肝段之间的变化及其与年龄和性别的关系。材料与方法:100名年龄在20-70岁的健康志愿者(50%为女性)行MRI检查。改进的Look-Locker反演恢复和多回波快速自旋回波序列分别用于测量肝脏原生全局和局部T1和T2值。讨论:肝脏T1、T2测图是可行的、可重复的,所提供的正常范围有助于确定各种肝脏疾病的诊断和进展。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
58
审稿时长
>12 weeks
期刊介绍: MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.
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