Analyzing the dynamic measurement of growth and development in children born after the transplantation of poor quality blastocyst embryos: a propensity matching study.
Chunmei Yu, Lijing Bai, Wanchao Zhang, Lin Feng, Xiaoyu Wang, Li Chen, Lingmin Hu
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引用次数: 0
Abstract
Objective: This study aimed to observe the dynamic measurement of growth and development in children (0-3 years) after transplantation of low-quality frozen-thawed single blastocysts.
Methods: This was a retrospective cohort study conducted from January 2016 to December 2019 at a single center. The follow-up data of the children were obtained from the Jiangsu Province Maternal and Child Database. A total of 350 singleton live births were included. Based on the blastocyst score, the live births were divided into good-quality blastocyst embryo (GQE) group (315 live births) and poor-quality blastocyst embryo (PQE) group (35 live births). To improve statistical efficiency and control for potential confounding factors, singletons conceived from PQEs were matched with a 3:1 ratio according to couple ages, BMI, occupation and women AMH levels. Ultimately, 32 children in the PQE group and 95 children (with one missing data) in the GQE group were included in the final analysis.
Results: After matching for parents' age, BMI, occupation and maternal serum AMH level, there was no significant difference in growth and development of children between the PQE group and GQE group. However, the E2 level on trigger days, the rate of 2PN oocyte, and blastocyst formation rate in the PQE group were significantly lower than in the GQE group (p < .05). The number of embryo transfers (ETs) in the PQE group was higher than in the GQE group (p < .0001). The rate of cesarean section in the PQE group was significantly higher than in the GQE group (p < .05). The height (at 3 months) and head circumference (at 12 months) in the PQE group were lower than in the GQE group (p < .05).
Conclusions: Transplantation of PQEs did not affect the growth and development of offspring (0-3 years) compared to good-quality blastocysts. However, the oocyte and embryo development potential was lower in the PQE group than in the GQE group. These results provide clinical reference that the transfer of PQE could be acceptable for patients with only PQE embryos.
目的:观察0 ~ 3岁儿童低质量冻融单囊胚移植后生长发育的动态变化。方法:这是一项回顾性队列研究，于2016年1月至2019年12月在单中心进行。儿童的随访数据来源于江苏省母婴数据库。共包括350名单胎活产婴儿。根据囊胚评分分为优质囊胚组(GQE) 315例和劣质囊胚组(PQE) 35例。为了提高统计效率和控制潜在的混杂因素，根据夫妇年龄、BMI、职业和女性AMH水平，以3:1的比例匹配PQEs的单胎。最终，PQE组32名儿童和GQE组95名儿童(其中1名数据缺失)被纳入最终分析。结果:经父母年龄、BMI、职业、母亲血清AMH水平匹配后，PQE组与GQE组患儿生长发育无显著差异。然而，触发日E2水平、2PN卵母细胞率和囊胚形成率PQE组显著低于GQE组(p p p p p)。结论:与优质囊胚相比，PQE组对子代(0-3岁)的生长发育没有影响。然而，PQE组的卵母细胞和胚胎发育潜力低于GQE组。这些结果为PQE胚胎移植在只有PQE胚胎的患者中是可以接受的提供了临床参考。
期刊介绍：
The Journal of Psychosomatic Obstetrics and Gynecology was founded in 1982 in order to provide a scientific forum for obstetricians, gynecologists, psychiatrists and psychologists, academic health professionals as well as for all those who are interested in the psychosocial and psychosomatic aspects of women’s health. Another of its aims is to stimulate obstetricians and gynecologists to pay more attention to this very important facet of their profession.
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