{"title":"Deubiquitinating enzymes for targeted cancer therapy","authors":"Yue Li, Xiaohui Wang","doi":"10.1002/ctd2.256","DOIUrl":null,"url":null,"abstract":"<p>In this commentary, we briefly introduce the ubiquitin-proteasome system and the potential targets for drug discovery in this system. We then outline the classification and function of deubiquitinating enzymes (DUBs) and discuss the molecular mechanism by which OTUB1 regulates the deubiquitination and function of cellular communication network factor 6, a specific tumour suppressor in breast cancer. Finally, we summarise the strategies for the regulation of DUBs at different levels.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":72605,"journal":{"name":"Clinical and translational discovery","volume":"3 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ctd2.256","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and translational discovery","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ctd2.256","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
In this commentary, we briefly introduce the ubiquitin-proteasome system and the potential targets for drug discovery in this system. We then outline the classification and function of deubiquitinating enzymes (DUBs) and discuss the molecular mechanism by which OTUB1 regulates the deubiquitination and function of cellular communication network factor 6, a specific tumour suppressor in breast cancer. Finally, we summarise the strategies for the regulation of DUBs at different levels.
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