Aging and Sex Differences in Brain Volume and Cerebral Blood Flow.

IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Aging and Disease Pub Date : 2024-10-01 DOI:10.14336/AD.2023.1122
Hiroto Kawano, Shigeki Yamada, Yoshiyuki Watanabe, Satoshi Ii, Tomohiro Otani, Hirotaka Ito, Ko Okada, Chifumi Iseki, Motoki Tanikawa, Shigeo Wada, Marie Oshima, Mitsuhito Mase, Kazumichi Yoshida
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Abstract

How do regional brain volume ratios and cerebral blood flow (CBF, mL/min) change with aging, and are there sex differences? This study aimed to comprehensively evaluate the relationships between regional brain volume ratios and CBF in healthy brains. The study participants were healthy volunteers who underwent three-dimensional T1-weighted MRI, time-of-flight MR angiography, and four-dimensional (4D) flow MRI between 2020 and 2022. The brain was automatically segmented into 21 brain subregions from 3D T1-weighted MRI, and CBF in 16 major intracranial arteries were measured by 4D flow MRI. The relationships between segmented brain volume ratios and CBFs around the circle of Willis were comprehensively investigated in each decade and sex. This study included 129 healthy volunteers (mean age ± SD, 48.2 ± 16.8; range, 22-92 years; 43 males and 86 females). The association was strongest between the cortical gray matter volume ratio and total outflow of the intracranial major arteries distal to the circle of Willis (Pearson's correlation coefficient, r: 0.425). In addition, the mean flow of the total inflow and outflow around the circle of Willis were significantly greater in women than men, and significant left-right differences were observed in CBFs even on the peripheral side of the circle of Willis. Moreover, the correlation was strongest between the left cortical gray matter volume ratio and the combined flows of the left anterior and posterior cerebral arteries distal to the circle of Willis (r: 0.486). There was a trend toward greater total intracranial CBF, especially among women in their 40s and younger, who had a larger cortical gray matter volume. This finding may be one of the reasons for the approximately twofold higher incidence of cerebral aneurysms and subarachnoid hemorrhage, and a threefold higher incidence of migraine headaches.

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脑容量和脑血流量的年龄和性别差异。
区域脑容量比和脑血流量(CBF, mL/min)如何随年龄变化,是否存在性别差异?本研究旨在全面评价健康大脑区域脑容量比与脑血流的关系。研究参与者是健康志愿者,他们在2020年至2022年间接受了三维t1加权MRI、飞行时间磁共振血管造影和四维(4D)血流MRI。3D t1加权MRI自动将脑分割为21个脑亚区,4D血流MRI测量16条颅内大动脉的脑血流。在每十年和性别中全面研究了分段脑容量比与威利斯圈周围cbf之间的关系。本研究纳入129名健康志愿者(平均年龄±SD, 48.2±16.8;范围:22-92岁;男性43人,女性86人)。皮层灰质体积比与Willis环远端颅内大动脉总流出量之间的相关性最强(Pearson相关系数,r: 0.425)。此外,女性在威利斯环周围的总流入和总流出的平均流量明显大于男性,即使在威利斯环的外周侧,cbf也存在显著的左右差异。此外,左侧皮质灰质体积比与Willis环远端左侧大脑前后动脉联合血流的相关性最强(r: 0.486)。总的颅内脑血流有增大的趋势,特别是在40岁及更年轻的女性中,她们的皮质灰质体积更大。这一发现可能是脑动脉瘤和蛛网膜下腔出血发生率大约高出两倍、偏头痛发生率高出三倍的原因之一。
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来源期刊
Aging and Disease
Aging and Disease GERIATRICS & GERONTOLOGY-
CiteScore
14.60
自引率
2.70%
发文量
138
审稿时长
10 weeks
期刊介绍: Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
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