Early Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Breast Cancer Treated with Eribulin After Prior Immuno-Oncology or Antibody-Drug Conjugate Therapy.

IF 3.3 4区 医学 Q2 ONCOLOGY Breast Cancer : Targets and Therapy Pub Date : 2023-11-17 eCollection Date: 2023-01-01 DOI:10.2147/BCTT.S422025
Ravi K Goyal, Jingchuan Zhang, Keith L Davis, Martina Sluga-O'Callaghan, Peter A Kaufman
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Abstract

Introduction: Eribulin was approved by the FDA in 2010 for the treatment of metastatic breast cancer (MBC) in the United States (US). More recently, several immuno-oncology (IO) and antibody-drug conjugate (ADC) regimens have been approved for MBC. We assessed the treatment patterns and clinical outcomes in MBC patients treated with eribulin following treatment with an IO or ADC in US clinical practice.

Materials and methods: In a retrospective patient medical chart review study, patients with MBC, aged ≥18 years, who initiated eribulin therapy between March 1, 2019, and September 30, 2020, treated with either prior IO or ADC in the metastatic setting were included. Patient demographics, treatment characteristics, and clinical outcomes were analyzed descriptively. Real-world progression-free survival (rwPFS) and overall survival (OS) were estimated using Kaplan-Meier analyses.

Results: In the study population (N=143), median age at eribulin initiation was 62 years; 64% were Caucasian, and 67% had triple-negative MBC (TNBC). Eribulin therapy was used in the second to fifth line of therapy in the metastatic setting; median treatment duration was 7.2 months. The overall response rate for eribulin was 59.4%. Median rwPFS and OS from eribulin initiation were 21.4 months (95% CI, 12.9-not estimable [NE]) and 24.2 months (95% CI, 17.5-NE), respectively. In patients with TNBC, median rwPFS and OS from eribulin initiation were 12.0 months (95% CI, 8.8-NE) and 18.3 months (95% CI, 14.9-NE), respectively.

Conclusion: These real-world data provide evidence for the clinical effectiveness outcomes of eribulin treatment among MBC patients previously treated with an IO or ADC.

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转移性乳腺癌患者在先前的免疫肿瘤或抗体-药物偶联治疗后接受艾力布林治疗的早期现实世界治疗模式和临床结果
简介:Eribulin于2010年获得美国FDA批准用于治疗转移性乳腺癌(MBC)。最近,一些免疫肿瘤学(IO)和抗体-药物偶联(ADC)方案已被批准用于MBC。在美国临床实践中,我们评估了在接受IO或ADC治疗后接受伊立布林治疗的MBC患者的治疗模式和临床结果。材料和方法:在一项回顾性患者病历回顾研究中,纳入了在2019年3月1日至2020年9月30日期间开始接受伊瑞布林治疗的年龄≥18岁的MBC患者,这些患者之前接受过转移性IO或ADC治疗。对患者人口统计学、治疗特征和临床结果进行描述性分析。使用Kaplan-Meier分析估计真实世界无进展生存期(rwPFS)和总生存期(OS)。结果:在研究人群(N=143)中,艾瑞布林开始治疗时的中位年龄为62岁;64%为白种人,67%为三阴性MBC (TNBC)。艾力布林治疗用于转移性肿瘤的第二至第五线治疗;中位治疗时间为7.2个月。伊瑞布林的总有效率为59.4%。伊瑞布林起始治疗后的中位rwPFS和OS分别为21.4个月(95% CI, 12.9-不可估计[NE])和24.2个月(95% CI, 17.5-NE)。在TNBC患者中,伊瑞布林起始的中位rwPFS和OS分别为12.0个月(95% CI, 8.8-NE)和18.3个月(95% CI, 14.9-NE)。结论:这些真实数据为先前接受过IO或ADC治疗的MBC患者的临床疗效提供了证据。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
40
审稿时长
16 weeks
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