Pushing the limits of treatment for hepatocellular carcinoma.

IF 1.8 4区 医学 Q3 TRANSPLANTATION Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2023-11-30 DOI:10.1097/MOT.0000000000001123
Michelle Jones-Pauley, David W Victor, Sudha Kodali
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Abstract

Purpose of review: We review existing and newer strategies for treatment and surveillance of hepatocellular carcinoma (HCC) both pre and postliver transplantation.

Summary: HCC is rising in incidence and patients are often diagnosed at later stages. Consequently, there is a need for treatment strategies which include collaboration of multiple specialties. Combinations of locoregional, systemic, and surgical therapies are yielding better postliver transplantation (post-LT) outcomes for patients with HCC than previously seen. Tumor biology (tumor size, number, location, serum markers, response to therapy) can help identify patients who are at high risk for HCC recurrence posttransplantation and may expand transplant eligibility for some patients.

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推动肝细胞癌治疗的极限。
综述目的:我们回顾了肝移植前后肝细胞癌(HCC)的治疗和监测的现有和更新的策略。摘要:HCC的发病率正在上升,患者往往在晚期才被诊断出来。因此,需要制定包括多专业合作在内的治疗策略。局部、全身和手术联合治疗肝癌患者肝移植后(后lt)的预后比以前所见的更好。肿瘤生物学(肿瘤大小、数量、位置、血清标志物、对治疗的反应)可以帮助识别移植后HCC复发的高危患者,并可能扩大一些患者的移植资格。
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来源期刊
CiteScore
4.10
自引率
4.50%
发文量
124
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
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