The Role of TRIM Proteins in Vascular Disease.

IF 2.8 3区医学 Q2 PERIPHERAL VASCULAR DISEASE Current vascular pharmacology Pub Date : 2024-01-01 DOI:10.2174/0115701611241848231114111618

Xinxin Chen, Xiaolong Chen

引用次数: 0

Abstract

There are more than 80 different tripartite motifs (TRIM) proteins within the E3 ubiquitin ligase subfamily, including proteins that regulate intracellular signaling, apoptosis, autophagy, proliferation, inflammation, and immunity through the ubiquitination of target proteins. Studies conducted in recent years have unraveled the importance of TRIM proteins in the pathophysiology of vascular diseases. In this review, we describe the effects of TRIM proteins on vascular endothelial cells, smooth muscle cells, heart, and lungs. In particular, we discuss the potential mechanisms by which TRIMs regulate diseases and shed light on the potential therapeutic applications of TRIMs.

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TRIM蛋白在血管疾病中的作用。

在E3泛素连接酶亚家族中有超过80种不同的TRIM蛋白，包括通过靶蛋白的泛素化调节细胞内信号传导、凋亡、自噬、增殖、炎症和免疫的蛋白。近年来进行的研究揭示了TRIM蛋白在血管疾病病理生理中的重要性。在这篇综述中，我们描述了TRIM蛋白对血管内皮细胞、平滑肌细胞、心脏和肺的影响。特别是，我们讨论了TRIMs调节疾病的潜在机制，并揭示了TRIMs潜在的治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current vascular pharmacology 医学-外周血管病

CiteScore

9.20

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Vascular Pharmacology publishes clinical and research-based reviews/mini-reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research. Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).