Complexing Properties of Synthesized 1,3,5-Triaza-7-Phosphaadamantane Derivatives Towards Some Lanthanides and Transition Metal Cations With Significant Antimicrobial and Antioxidant Activities.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2023-11-16 eCollection Date: 2023-10-01 DOI:10.1177/15593258231216274

Lassaad Baklouti, Besma Mellah, Waleed S Koko

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Abstract

The synthesis of new water-soluble N-alkylated derivatives of 1,3,5-triaza-7-phosphaadamantane is presented. Ru(PPh₃)₂Cl₂ has been used to react with 1-(4-nitrobenzyl)-3,5-triaza-1-azonia-7-phosphaadamantane bromide (PTAR). By using elemental analysis, NMR, and IR spectroscopy, the obtained compounds were identified. The UV-visible absorption spectroscopy has been used to monitor the complexation of various transition metal cations. Studies on conductivity have been utilized to validate the complexes' stoichiometries. Using the disc diffusion method, five bacteria strains were used for the study of the antimicrobial activity of compounds 1-3. All tested pathogens, including M luteus LB 141107, were found to have strong biologic activity against the compounds tested in this study. Additionally, DPPH (2,2-diphenyl-1-picrylhydrazyl) has been tested for its ability to scavenge hydrogen peroxide and free radicals. According to our results, these compounds exhibit excellent radical scavenging properties.

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合成的1,3,5-三氮杂-7-磷金刚烷衍生物与某些具有显著抗菌和抗氧化活性的镧系元素和过渡金属阳离子的络合性能

合成了新的水溶性n -烷基化1,3,5-三氮杂-7-磷金刚烷衍生物。用Ru(PPh3)2Cl2与1-(4-硝基苄基)-3,5-三氮杂-1-氮杂-7-磷酸金刚烷溴(PTAR)反应。通过元素分析、核磁共振和红外光谱对所得化合物进行了鉴定。采用紫外可见吸收光谱法对各种过渡金属阳离子的络合进行了监测。利用电导率的研究来验证配合物的化学计量。采用圆盘扩散法，对5株菌株进行了化合物1 ~ 3的抑菌活性研究。所有检测的病原菌，包括M luteus LB 141107，均对本研究检测的化合物具有较强的生物活性。此外，DPPH(2,2-二苯基-1-吡啶酰肼)已被测试其清除过氧化氢和自由基的能力。根据我们的研究结果，这些化合物表现出优异的自由基清除性能。

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