Echocardiographic Phenotypes of Subclinical Organ Damage: Clinical and Prognostic Value in the General Population. Findings from the Pamela Study.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE High Blood Pressure & Cardiovascular Prevention Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI:10.1007/s40292-023-00610-4
Cesare Cuspidi, Andrea Faggiano, Giuseppe Mancia, Guido Grassi
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Abstract

Subclinical alterations in cardiac structure and function include a variety of abnormal phenotypes of established adverse prognostic significance such as left ventricular hypertrophy (LVH), alterations of LV geometry, left atrial (LA) enlargement, and aortic root (AR) dilatation. The excess cardiovascular (CV) risk associated with these phenotypes has been consistently demonstrated in different clinical settings such in patients with systemic hypertension, coronary heart disease, diabetes mellitus, chronic kidney disease, heart failure and in geneal population samples. The Pressioni Monitorate e Loro Associazioni (PAMELA), a longitudinal population-based study originally designed to assess the normality values, prognostic significance of office, home and 24-hour blood pressure, including among the many clinical and laboratory variables the collection of echocardiographic data, allowed to gather important information on the clinical prognostic significance of subclinical cardiac damage during a long follow-up period. This article summarizes the original findings provided by the PAMELA study on the clinical correlates and prognostic significance of echocardiographic markers of subclinical organa damage namely LVH, left atrial enlargement (LA) and AR dilatation at the community level.

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亚临床器官损害的超声心动图表型:在一般人群中的临床和预后价值。帕梅拉研究的发现。
心脏结构和功能的亚临床改变包括各种具有不良预后意义的异常表型,如左室肥厚(LVH)、左室几何形状改变、左房(LA)扩大和主动脉根(AR)扩张。与这些表型相关的过多心血管(CV)风险已在不同的临床环境中得到一致证明,例如患有全身性高血压、冠心病、糖尿病、慢性肾病、心力衰竭的患者和一般人群样本。血压监测协会(PAMELA)是一项基于人群的纵向研究,最初旨在评估办公室、家庭和24小时血压的正常值和预后意义,包括超声心动图数据收集的许多临床和实验室变量,允许在长时间随访期间收集亚临床心脏损伤的临床预后意义的重要信息。本文综述了PAMELA在社区水平上对亚临床器官损伤超声心动图指标LVH、左房扩张(LA)和AR扩张的临床相关性及预后意义的初步研究结果。
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来源期刊
CiteScore
5.70
自引率
3.30%
发文量
57
期刊介绍: High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes:   Invited ''State of the Art'' reviews.  Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.
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