A Prospective Randomized Study of the Herbal Medicine Yokukansan for Preventing Delirium After Gastrointestinal Cancer Surgery.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Yonago acta medica Pub Date : 2023-11-28 eCollection Date: 2023-11-01 DOI:10.33160/yam.2023.11.008

Akimitsu Tanio, Manabu Yamamoto, Chihiro Uejima, Yoichiro Tada, Takehiko Yamanashi, Ryoichi Matsuo, Akihiko Miura, Naofumi Kajitani, Tsuyoshi Nishiguchi, Masaaki Iwata, Yoshiyuki Fujiwara

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Abstract

Background: Yokukansan, the Chinese Herbal Medicine, may be effective for treating postoperative delirium. However, there is no sufficient evidence supporting this notion. This study aimed to investigate whether yokukansan was effective for preventing delirium after gastrointestinal cancer surgery by the prospective randomized study.

Methods: This was a double-blind, randomized, controlled trial. Patients aged 75 years or older who underwent surgery between May 2017 and December 2019 were randomized to the yokukansan or anchusan (another Herbal Medicine) group. They received treatments with oral intake of assigned medicine from the day before surgery until postoperative day 3. Then, the incidence of postoperative delirium was compared. A psychiatrist diagnosed patients with postoperative delirium.

Results: Seventy-seven patients were enrolled in this study, and the full analysis set comprised 68 patients. In total, 25 of 68 (36.8%) patients presented with postoperative delirium. Specifically, 13 (37.1%) patients in the control group and 12 (36.4%) in the yokukansan group were diagnosed with postoperative delirium. However, the results did not differ significantly in both groups. Moreover, there was no remarkable difference in terms of delirium severity, and adverse events correlated with the medications were not observed.

Conclusion: Yokukansan was ineffective in preventing delirium after gastrointestinal cancer surgery.

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一项前瞻性随机研究:中药Yokukansan预防胃肠道肿瘤术后谵妄。

背景:中药“横山”治疗术后谵妄可能有效。然而，没有足够的证据支持这一观点。本研究旨在通过前瞻性随机研究，探讨横坎散对预防胃肠道肿瘤术后谵妄是否有效。方法:双盲、随机、对照试验。在2017年5月至2019年12月期间接受手术的75岁及以上患者被随机分配到yokukansan或anchusan(另一种草药)组。患者术前至术后第3天口服指定药物治疗。比较两组术后谵妄的发生率。精神科医生诊断病人术后谵妄。结果:本研究纳入77例患者，完整分析集包括68例患者。68例患者中有25例(36.8%)出现术后谵妄。其中，对照组13例(37.1%)，横山组12例(36.4%)出现术后谵妄。然而，两组的结果并没有显著差异。此外，在谵妄严重程度方面没有显著差异，未观察到与药物相关的不良事件。结论:横坎散对胃肠道肿瘤术后谵妄的预防效果较差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Yonago acta medica MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Yonago Acta Medica (YAM) is an electronic journal specializing in medical sciences, published by Tottori University Medical Press, 86 Nishi-cho, Yonago 683-8503, Japan. The subject areas cover the following: molecular/cell biology; biochemistry; basic medicine; clinical medicine; veterinary medicine; clinical nutrition and food sciences; medical engineering; nursing sciences; laboratory medicine; clinical psychology; medical education. Basically, contributors are limited to members of Tottori University and Tottori University Hospital. Researchers outside the above-mentioned university community may also submit papers on the recommendation of a professor, an associate professor, or a junior associate professor at this university community. Articles are classified into four categories: review articles, original articles, patient reports, and short communications.