Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies.

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2023-12-01 Epub Date: 2023-12-02 DOI:10.1080/13510002.2023.2272386

Jie Gao, Liming Tao, Zhengxuan Jiang

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引用次数: 0

Abstract

Objectives: This review outlines the function of oxidative stress in DR and discusses therapeutic strategies to treat DR with antioxidants.

Methods: Published papers on oxidative stress in DR and therapeutic strategies to treat DR with antioxidants were collected and reviewed via database searching on PubMed.

Results: The abnormal development of DR is a complicated process. The pathogenesis of DR has been reported to involve oxidative stress, despite the fact that the mechanisms underlying this are still not fully understood. Excessive reactive oxygen species (ROS) accumulation can damage retina, eventually leading to DR. Increasing evidence have demonstrated that antioxidant therapy can alleviate the degeneration of retinal capillaries in DR.

Conclusion: Oxidative stress can play an important contributor in the pathogenesis of DR. Furthermore, animal experiments have shown that antioxidants are a beneficial therapy for treating DR, but more clinical trial data is needed.

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减轻糖尿病视网膜病变的氧化应激:抗氧化治疗策略。

目的:本文综述了氧化应激在DR中的作用，并讨论了抗氧化剂治疗DR的治疗策略。方法:通过PubMed数据库检索，收集已发表的DR氧化应激及抗氧化剂治疗DR的相关文献。结果:DR的异常发展是一个复杂的过程。据报道，DR的发病机制与氧化应激有关，尽管其机制尚不完全清楚。越来越多的证据表明，抗氧化治疗可以减轻DR视网膜毛细血管的变性。结论:氧化应激在DR的发病机制中起重要作用。动物实验表明抗氧化剂是治疗DR的有益药物，但还需要更多的临床试验数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.