Effects of administration of local aminophylline on patients undergoing ureteroscopic lithotripsy.

IF 0.8 Q4 UROLOGY & NEPHROLOGY Urologia Journal Pub Date : 2024-08-01 Epub Date: 2023-12-02 DOI:10.1177/03915603231216141
Anantbir Singh Lubana, Shivam Priyadarshi, Govind Sharma, Somendra Bansal, Neeraj Agarwal, Nachiket Vyas
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Abstract

Introduction: The presence of ureteral stones can cause pain, infections of urinary tract and hydronephrosis, resulting in the loss of renal function. For two decades, Ureteroscopy and laser stone fragmentation (URSL) attained a big rise and is the first line management for large ureteric stones and renal stones up to 2 cm. The present study was conducted to assess the success rate of ureteroscopic lithotripsy in treatment of ureteric calculus after local administration of aminophylline.

Materials and methods: 100 patients having ureteric calculi <20 mm in size, aged 20-60 years were included in the study and randomly divided into Group A (n = 50) with administration of local aminophylline and Group B (n = 50) with administration of saline infusion. Ureteroscopy was performed after 5 min of administration of the solution. URSL was done using pneumatic lithoclast and/or laser. Various parameters like duration of procedure, ease of ureteral access, requirement of DJ Stent and need of further operative interventions were compared between case and control groups. The data was collected and then subjected to statistical analysis using IBM SPSS 20.0 version at significance level of p < 0.05.

Results: The mean age of study subjects having ureteral stones was found to be between 31 and 40 years of age with males being more affected. We observed less mean duration of surgery, higher success rate, easy ureteral access (p-value < 0.05) with aminophylline use than control group. The need of ureteral stent and Auxiliary procedures was significantly higher in the control than in the case group (38%).

Conclusion: The use of aminophylline has been found to be highly useful and effective in reducing the need of stents and secondary surgery, decreased pain, and increased success rate. Thus, the use of aminophylline is recommended during URSL procedure for the successful management of ureteral calculi.

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输尿管镜碎石术中局部给药氨茶碱的影响。
导读:输尿管结石的存在可引起疼痛、尿路感染和肾积水,导致肾功能丧失。近二十年来,输尿管镜检查和激光碎石术(URSL)得到了很大的发展,成为大输尿管结石和2厘米以下肾结石的一线治疗方法。本研究旨在评估输尿管镜下碎石术治疗输尿管结石局部给予氨茶碱后的成功率。材料与方法:输尿管结石患者100例(50例)给予局部氨茶碱治疗,B组(50例)给予生理盐水输注。给药5分钟后行输尿管镜检查。URSL采用气动碎石和/或激光进行。比较病例组与对照组手术时间、输尿管通路难易程度、DJ支架需要量及进一步手术干预需求等参数。收集资料,采用IBM SPSS 20.0版本进行统计学分析,在p的显著性水平上进行统计学分析。结果:研究对象输尿管结石的平均年龄在31 ~ 40岁之间,男性多见。我们观察到平均手术时间短,成功率高,输尿管通路容易(p值)结论:氨茶碱的使用对减少支架和二次手术的需要,减轻疼痛,提高成功率非常有用和有效。因此,建议在URSL手术中使用氨茶碱以成功治疗输尿管结石。
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来源期刊
Urologia Journal
Urologia Journal UROLOGY & NEPHROLOGY-
CiteScore
0.60
自引率
12.50%
发文量
66
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