Impact of NAD+ metabolism on ovarian aging.

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY Immunity & Ageing Pub Date : 2023-12-02 DOI:10.1186/s12979-023-00398-w
Jinghui Liang, Feiling Huang, Zhaoqi Song, Ruiyi Tang, Peng Zhang, Rong Chen
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Abstract

Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-related functional degeneration and metabolic diseases. NAD exerts direct and indirect influences on many crucial cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cellular senescence, and immune cell functionality. These cellular processes and functions are essential for maintaining tissue and metabolic homeostasis, as well as healthy aging. Causality has been elucidated between a decline in NAD levels and multiple age-related diseases, which has been confirmed by various strategies aimed at increasing NAD levels in the preclinical setting. Ovarian aging is recognized as a natural process characterized by a decline in follicle number and function, resulting in decreased estrogen production and menopause. In this regard, it is necessary to address the many factors involved in this complicated procedure, which could improve fertility in women of advanced maternal age. Concerning the decrease in NAD+ levels as ovarian aging progresses, promising and exciting results are presented for strategies using NAD+ precursors to promote NAD+ biosynthesis, which could substantially improve oocyte quality and alleviate ovarian aging. Hence, to acquire further insights into NAD+ metabolism and biology, this review aims to probe the factors affecting ovarian aging, the characteristics of NAD+ precursors, and the current research status of NAD+ supplementation in ovarian aging. Specifically, by gaining a comprehensive understanding of these aspects, we are optimistic about the prominent progress that will be made in both research and therapy related to ovarian aging.

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NAD+代谢对卵巢衰老的影响。
烟酰胺腺嘌呤二核苷酸(NAD+)是细胞氧化还原反应中重要的辅酶,与年龄相关的功能退化和代谢性疾病密切相关。NAD对许多重要的细胞功能产生直接和间接的影响,包括代谢途径、DNA修复、染色质重塑、细胞衰老和免疫细胞功能。这些细胞过程和功能对于维持组织和代谢稳态以及健康衰老至关重要。NAD水平下降与多种年龄相关疾病之间的因果关系已被阐明,这已被临床前环境中旨在提高NAD水平的各种策略所证实。卵巢衰老被认为是一个自然过程,其特征是卵泡数量和功能下降,导致雌激素分泌减少和更年期。在这方面,有必要处理这一复杂程序所涉及的许多因素,它可以提高高龄产妇的生育能力。随着卵巢衰老,NAD+水平下降,利用NAD+前体促进NAD+生物合成的策略有望显著改善卵母细胞质量,缓解卵巢衰老。因此,为了进一步了解NAD+的代谢和生物学,本文旨在探讨影响卵巢衰老的因素、NAD+前体的特征以及补充NAD+在卵巢衰老中的研究现状。具体而言,通过对这些方面的全面了解,我们对与卵巢衰老相关的研究和治疗将取得显著进展持乐观态度。
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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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