Input-size dependence of the baroreflex neural arc transfer characteristics during Gaussian white noise inputs.

IF 2.2 3区 医学 Q3 PHYSIOLOGY American journal of physiology. Regulatory, integrative and comparative physiology Pub Date : 2024-02-01 Epub Date: 2023-12-04 DOI:10.1152/ajpregu.00199.2023
Toru Kawada, Tadayoshi Miyamoto, Masafumi Fukumitsu, Keita Saku
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Abstract

Although Gaussian white noise (GWN) inputs offer a theoretical framework for identifying higher-order nonlinearity, an actual application to the data of the neural arc of the carotid sinus baroreflex did not succeed in fully predicting the well-known sigmoidal nonlinearity. In the present study, we assumed that the neural arc can be approximated by a cascade of a linear dynamic (LD) component and a nonlinear static (NS) component. We analyzed the data obtained using GWN inputs with a mean of 120 mmHg and standard deviations (SDs) of 10, 20, and 30 mmHg for 15 min each in anesthetized rats (n = 7). We first estimated the linear transfer function from carotid sinus pressure to sympathetic nerve activity (SNA) and then plotted the measured SNA against the linearly predicted SNA. The predicted and measured data pairs exhibited an inverse sigmoidal distribution when grouped into 10 bins based on the size of the linearly predicted SNA. The sigmoidal nonlinearity estimated via the LD-NS model showed a midpoint pressure (104.1 ± 4.4 mmHg for SD of 30 mmHg) lower than that estimated by a conventional stepwise input (135.8 ± 3.9 mmHg, P < 0.001). This suggests that the NS component is more likely to reflect the nonlinearity observed during pulsatile inputs that are physiological to baroreceptors. Furthermore, the LD-NS model yielded higher R2 values compared with the linear model and the previously suggested second-order Uryson model in the testing dataset.NEW & NOTEWORTHY We examined the input-size dependence of the baroreflex neural arc transfer characteristics during Gaussian white noise inputs. A linear dynamic-static nonlinear model yielded higher R2 values compared with a linear model and captured the well-known sigmoidal nonlinearity of the neural arc, indicating that the nonlinear dynamics contributed to determining sympathetic nerve activity. Ignoring such nonlinear dynamics might reduce our ability to explain underlying physiology and significantly limit the interpretation of experimental data.

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高斯白噪声输入下压力反射神经弧传递特性的输入大小依赖性。
尽管高斯白噪声(GWN)输入为识别高阶非线性提供了理论框架,但对颈动脉窦压力反射神经弧数据的实际应用并不能成功地完全预测众所周知的s型非线性。在本研究中,我们假设神经弧可以用线性动态(LD)分量和非线性静态(NS)分量的级联来近似。我们分析了麻醉大鼠(n = 7)使用GWN输入(平均120 mmHg,标准差10、20和30 mmHg,各15分钟)获得的数据。我们首先估计了颈动脉窦压到交感神经活动(SNA)的线性传递函数,然后绘制了测量的SNA与线性预测的SNA的对比图。根据线性预测SNA的大小,将预测和测量的数据对分成10个箱时,呈现逆s型分布。通过LD-NS模型估计的s型非线性显示,SD为30 mmHg时,中点压力(104.1±4.4 mmHg)低于传统逐步输入估计的中点压力(135.8±3.9 mmHg, P < 0.001)。这表明,NS成分更有可能反映在脉动输入期间观察到的非线性,这对压力感受器来说是生理的。此外,在测试数据集中,LD-NS模型比线性模型和先前建议的二阶Uryson模型产生更高的R2值。
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来源期刊
CiteScore
5.30
自引率
3.60%
发文量
145
审稿时长
2 months
期刊介绍: The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; glucose homeostasis and energy balance; appetite and obesity; inflammation and cytokines; integrative physiology of pregnancy-parturition-lactation; and thermoregulation and adaptations to exercise and environmental stress.
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