Aino Saarinen, Jarmo Hietala, Leo-Pekka Lyytikäinen, Binisha Hamal Mishra, Elina Sormunen, Veikka Lavonius, Mika Kähönen, Olli Raitakari, Terho Lehtimäki, Liisa Keltikangas-Järvinen
{"title":"Polygenic risk for schizophrenia predicting social trajectories in a general population sample.","authors":"Aino Saarinen, Jarmo Hietala, Leo-Pekka Lyytikäinen, Binisha Hamal Mishra, Elina Sormunen, Veikka Lavonius, Mika Kähönen, Olli Raitakari, Terho Lehtimäki, Liisa Keltikangas-Järvinen","doi":"10.1017/S003329172300346X","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>We investigated (a) whether polygenic risk for schizophrenia predicts different trajectories of social development among those who have not developed psychoses and (b) whether possible associations are PRS<sub>SCZ</sub>-specific or evident also for any polygenic risk for mental disorders, e.g. for major depression.</p><p><strong>Methods: </strong>Participants came from the population-based Young Finns Study (<i>n</i> = 2377). We calculated a polygenic risk score for schizophrenia (PRS<sub>SCZ</sub>) and for major depression (PRS<sub>DEP</sub>). Diagnoses of psychotic disorders were derived from the hospital care register. Social development from adolescence to middle age was measured by (a) perceived social support from friends, family, and a close other, (b) perceived sociability, and (c) family structure (partnership status, number of children, age of first-time parenthood).</p><p><strong>Results: </strong>Among those without manifest psychoses, high PRS<sub>SCZ</sub> predicted lower experienced support from friends (<i>B</i> = -0.04, <i>p</i> = 0.009-0.035) and family (<i>B</i> = -0.04, <i>p</i> = 0.009-0.035) especially after early adulthood, and also lower perceived sociability (<i>B</i> = -0.05, <i>p</i> = 0.010-0.026). PRS<sub>SCZ</sub> was not related to family structure. PRS<sub>DEP</sub> did not predict any domain of social development.</p><p><strong>Conclusions: </strong>Individuals at high PRS<sub>SCZ</sub> (not converted to psychosis) seem to experience a lower preference to be with others over being alone. Individuals with high (<i>v.</i> low) PRS<sub>SCZ</sub> seem to have a similar family structure in terms of partnership status or number of children but, nevertheless, they experience less support from their family. Among those not converted to psychosis in a typical age period, high PRS<sub>SCZ</sub> may predict a 'later risk phase' and reduced functional resilience when approaching middle age.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":5.9000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychological Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S003329172300346X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: We investigated (a) whether polygenic risk for schizophrenia predicts different trajectories of social development among those who have not developed psychoses and (b) whether possible associations are PRSSCZ-specific or evident also for any polygenic risk for mental disorders, e.g. for major depression.
Methods: Participants came from the population-based Young Finns Study (n = 2377). We calculated a polygenic risk score for schizophrenia (PRSSCZ) and for major depression (PRSDEP). Diagnoses of psychotic disorders were derived from the hospital care register. Social development from adolescence to middle age was measured by (a) perceived social support from friends, family, and a close other, (b) perceived sociability, and (c) family structure (partnership status, number of children, age of first-time parenthood).
Results: Among those without manifest psychoses, high PRSSCZ predicted lower experienced support from friends (B = -0.04, p = 0.009-0.035) and family (B = -0.04, p = 0.009-0.035) especially after early adulthood, and also lower perceived sociability (B = -0.05, p = 0.010-0.026). PRSSCZ was not related to family structure. PRSDEP did not predict any domain of social development.
Conclusions: Individuals at high PRSSCZ (not converted to psychosis) seem to experience a lower preference to be with others over being alone. Individuals with high (v. low) PRSSCZ seem to have a similar family structure in terms of partnership status or number of children but, nevertheless, they experience less support from their family. Among those not converted to psychosis in a typical age period, high PRSSCZ may predict a 'later risk phase' and reduced functional resilience when approaching middle age.
期刊介绍:
Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.