Bictegravir/Emtricitabine/Tenofovir Alafenamide for HIV-1: What is the Hidden Potential of This Emerging Treatment?

IF 1.5 Q4 INFECTIOUS DISEASES HIV AIDS-Research and Palliative Care Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI:10.2147/HIV.S385877

Jenna E Januszka, Emily N Drwiega, Melissa E Badowski

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Abstract

Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) is a single-tablet antiretroviral therapy regimen. B/F/TAF has become a popular treatment choice because of its small tablet size, high barrier to resistance, favorable tolerability, and limited drug-drug interaction profile. Continued research on B/F/TAF has revealed additional potential for this regimen. This review presents recent literature supporting the use of B/F/TAF as an option for consolidating therapy and maintaining virologic suppression in individuals despite M184V/I mutations. Additionally, children are a unique patient population with limited antiviral options. Standard dose B/F/TAF has demonstrated similar drug exposure in children and adolescents as adults, and low-dose B/F/TAF is approved for children living with HIV greater than two years of age and weighing at least 14 kg. Data supporting this recommendation is described in this review. Finally, despite a lack of prospective data, B/F/TAF may have a role in the future of pre- and post-exposure prophylaxis. This review discusses these discoveries and the continued exploration of the hidden potential of B/F/TAF.

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比替格拉韦/恩曲他滨/替诺福韦阿拉芬胺治疗HIV-1:这种新兴治疗方法的潜在潜力是什么?

比替格拉韦/恩曲他滨/替诺福韦阿拉那胺(B/F/TAF)是一种单片抗逆转录病毒治疗方案。B/F/TAF因其片剂小、耐药屏障高、耐受性好、药物-药物相互作用有限而成为一种流行的治疗选择。对B/F/TAF的持续研究揭示了该方案的额外潜力。本文综述了最近的文献，支持在M184V/I突变的个体中使用B/F/TAF作为巩固治疗和维持病毒学抑制的选择。此外，儿童是一个独特的患者群体，抗病毒药物的选择有限。标准剂量B/F/TAF已证明儿童和青少年的药物暴露与成人相似，低剂量B/F/TAF已被批准用于2岁以上、体重至少14公斤的艾滋病毒感染儿童。本综述描述了支持这一建议的数据。最后，尽管缺乏前瞻性数据，B/F/TAF可能在未来暴露前和暴露后预防中发挥作用。本文将讨论这些发现，并继续探索B/F/TAF的潜在潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HIV AIDS-Research and Palliative Care INFECTIOUS DISEASES-

CiteScore

3.00

自引率

6.70%

发文量

审稿时长

16 weeks

期刊介绍： About Dove Medical Press Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC. We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine. Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ''best of breed'' new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand. Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.