Tribological behavior of shape-specific microplate-enriched synovial fluids on a linear two-axis tribometer

IF 6.3 1区 工程技术 Q1 ENGINEERING, MECHANICAL Friction Pub Date : 2023-12-04 DOI:10.1007/s40544-023-0794-y
Agnese Fragassi, Antonietta Greco, Martina Di Francesco, Luca Ceseracciu, Aiman Abu Ammar, Israel Dvir, Thomas Lee Moore, Haytam Kasem, Paolo Decuzzi
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Abstract

Nano- and micro-particles are being increasingly used to tune interfacial frictional properties in diverse applications, from friction modifiers in industrial lubrication to enhanced biological fluids in human osteoarthritic joints. Here, we assessed the tribological properties of a simulated synovial fluid enriched with non-spherical, poly lactic-co-glycolic acid (PLGA) microparticles (µPL) that have been previously demonstrated for the pharmacological management of osteoarthritis (OA). Three different µPL configurations were fabricated presenting a 20 µm × 20 µm square base and a thickness of 5 µm (thin, 5H µPL), 10 µm (10H µPL), and 20 µm (cubical, 20H µPL). After extensive morphological and physicochemical characterizations, the apparent Young’s modulus of the µPL was quantified under compressive loading returning an average value of ∼ 6 kPa, independently of the particle morphology. Then, using a linear two-axis tribometer, the static (µs) and dynamic (µd) friction coefficients of the µPL-enriched simulated synovial fluid were determined in terms of particle configuration and concentration, varying from 0 (fluid only) to 6µ105 µPL/mL. The particle morphology had a modest influence on friction, possibly because the µPL were fully squeezed between two mating surfaces by a 5.8 N normal load realizing boundary-like lubrication conditions. Differently, friction was observed to depend on the dimensionless parameter Ω, defined as the ratio between the total volume of the µPL enriching the simulated synovial fluid and the volume of the fluid itself. Both coefficients of friction were documented to grow with Ω reaching a plateau of µs ∼ 0.4 and µd ∼ 0.15, already at Ω ∼ 2×10−3. Future investigations will have to systematically analyze the effect of sliding velocity, normal load, and rigidity of the mating surfaces to elucidate in full the tribological behavior of µPL in the context of osteoarthritis.

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形状特异性微板富集滑液在线性双轴摩擦计上的摩擦学行为
从工业润滑中的摩擦改性剂到人类骨关节炎关节中的增强生物流体,纳米和微颗粒正越来越多地用于调整各种应用中的界面摩擦特性。在这里,我们评估了富含非球形聚乳酸-羟基乙酸(PLGA)微颗粒(µPL)的模拟滑液的摩擦学特性,该微颗粒先前已被证明可用于骨关节炎(OA)的药理学治疗。制作了三种不同的µPL结构,分别为20µm × 20µm方形底座,厚度为5µm(薄,5HµPL), 10µm (10HµPL)和20µm(立方体,20HµPL)。经过广泛的形态和物理化学表征,μ PL的表观杨氏模量在压缩载荷下被量化,返回平均值为~ 6 kPa,与颗粒形态无关。然后,使用线性双轴摩擦计,根据颗粒结构和浓度确定富含μ PL的模拟滑液的静态(µs)和动态(µd)摩擦系数,范围从0(仅流体)到6µ105 μ PL/mL。颗粒形态对摩擦的影响不大,这可能是因为µPL在5.8 N的法向载荷下被完全挤压在两个配合表面之间,实现了类似边界的润滑条件。不同的是,观察到的摩擦取决于无因次参数Ω,该参数定义为模拟滑液中富集的μ PL的总体积与流体本身体积之间的比率。两种摩擦系数都有增长的记录,Ω达到平台期µs ~ 0.4和µd ~ 0.15,已经在Ω ~ 2×10−3。未来的研究必须系统地分析滑动速度、正常载荷和配合表面刚度的影响,以充分阐明µPL在骨关节炎背景下的摩擦学行为。
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来源期刊
Friction
Friction Engineering-Mechanical Engineering
CiteScore
12.90
自引率
13.20%
发文量
324
审稿时长
13 weeks
期刊介绍: Friction is a peer-reviewed international journal for the publication of theoretical and experimental research works related to the friction, lubrication and wear. Original, high quality research papers and review articles on all aspects of tribology are welcome, including, but are not limited to, a variety of topics, such as: Friction: Origin of friction, Friction theories, New phenomena of friction, Nano-friction, Ultra-low friction, Molecular friction, Ultra-high friction, Friction at high speed, Friction at high temperature or low temperature, Friction at solid/liquid interfaces, Bio-friction, Adhesion, etc. Lubrication: Superlubricity, Green lubricants, Nano-lubrication, Boundary lubrication, Thin film lubrication, Elastohydrodynamic lubrication, Mixed lubrication, New lubricants, New additives, Gas lubrication, Solid lubrication, etc. Wear: Wear materials, Wear mechanism, Wear models, Wear in severe conditions, Wear measurement, Wear monitoring, etc. Surface Engineering: Surface texturing, Molecular films, Surface coatings, Surface modification, Bionic surfaces, etc. Basic Sciences: Tribology system, Principles of tribology, Thermodynamics of tribo-systems, Micro-fluidics, Thermal stability of tribo-systems, etc. Friction is an open access journal. It is published quarterly by Tsinghua University Press and Springer, and sponsored by the State Key Laboratory of Tribology (TsinghuaUniversity) and the Tribology Institute of Chinese Mechanical Engineering Society.
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