The surgical and clinicopathological characteristics of primary mucinous ovarian cancer: a single institution 30-year retrospective analysis.

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY Journal of the Turkish German Gynecological Association Pub Date : 2023-12-06 DOI:10.4274/jtgga.galenos.2023.2022-8-1

Okan Aytekin, Dilek Yüksel, Okan Oktar, Caner Çakır, Günsu Kimyon Cömert, Vakkas Korkmaz, Yaprak Engin-Üstün, Taner Turan

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Abstract

Objective: To evaluate the clinicopathological characteristics of primary mucinous ovarian carcinoma (MOC) and define oncologic outcomes.

Material and methods: This retrospective study reviewed patients diagnosed with primary MOC at a single institution and underwent primary treatment between 1990 and 2019. The clinicopathological factors affecting oncological outcomes and treatment response were evaluated. The Kaplan-Meier method was used to evaluate survival outcomes. Survival curves were compared using the log-rank test.

Results: The cohort's (n=92) median (range) age was 48 (15-82) years. Seventy-five (81.5%) patients were in the International Federation of Gynecology and Obstetrics stage I-II. Forty patients received platinum-based adjuvant chemotherapy. The 5-year progression-free survival was 98% in stage I-II and 17% for stage III-IV (p<0.001). In multivariate analysis, the only independent risk factor for disease failure was stage (hazard ratio: 6.838, 95% confidence interval: 1,358-34,415; p=0.020).

Conclusion: Advanced stage was an independent poor prognostic factor for recurrence in patient with MOC.

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原发性粘液性卵巢癌的手术和临床病理特征：单机构 30 年回顾性分析。

摘要评估原发性黏液性卵巢癌（MOC）的临床病理特征，并确定肿瘤治疗结果：这项回顾性研究回顾了1990年至2019年期间在一家机构确诊并接受初治的原发性粘液性卵巢癌患者。评估了影响肿瘤预后和治疗反应的临床病理因素。采用 Kaplan-Meier 法评估生存结果。使用对数秩检验比较生存曲线：组群（92 人）的中位年龄（范围）为 48（15-82）岁。75名（81.5%）患者属于国际妇产科联盟I-II期。40名患者接受了铂类辅助化疗。I-II期患者的5年无进展生存率为98%，III-IV期患者为17%（P结论：晚期是MOC患者复发的一个独立不良预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Turkish German Gynecological Association OBSTETRICS & GYNECOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

期刊介绍： Journal of the Turkish-German Gynecological Association is the official, open access publication of the Turkish-German Gynecological Education and Research Foundation and Turkish-German Gynecological Association and is published quarterly on March, June, September and December. It is an independent peer-reviewed international journal printed in English language. Manuscripts are reviewed in accordance with “double-blind peer review” process for both reviewers and authors. The target audience of Journal of the Turkish-German Gynecological Association includes gynecologists and primary care physicians interested in gynecology practice. It publishes original works on all aspects of obstertrics and gynecology. The aim of Journal of the Turkish-German Gynecological Association is to publish high quality original research articles. In addition to research articles, reviews, editorials, letters to the editor, diagnostic puzzle are also published. Suggestions for new books are also welcomed. Journal of the Turkish-German Gynecological Association does not charge any fee for article submission or processing.