Short tandem repeat (STR) variation from 6 cities in Iraq based on 15 loci.

IF 3.6 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal, genetic engineering & biotechnology Pub Date : 2023-12-05 DOI:10.1186/s43141-023-00570-1
Majeed A Sabbah, Mohammed M Al-Zubaidi, Thooalnoon Y Al-Janabi, Dhuha S Namaa, Haider K Al-Rubai, Hala K Ibrahem
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Abstract

Background: One thousand sixty-one individuals were sampled from the cities of Anbar, Baghdad, Basra, Diyala, Najaf, and Wasit in Iraq and typed for 15 forensic STRs to explore the genetic structure of Iraq and develop a forensic DNA database. The total number of alleles that were identified was 203.

Result: Analyses of molecular variance (AMOVA) were then conducted Baghdad provides a good representation of the rest of the country, while Anbar is the most genetically distinct. The average heterozygosities of these loci was 0.779, homozygosities was 0.221, polymorphism information content was 0.77, power of discrimination was 0.927, and power of exclusion was 0.563. At these loci, a matching genotype will occur, on average, in 1 in 8.152 × 1017 individuals. For paternity tests, the average paternity probability for a matching profile is 99.9997%.

Conclusions: These loci are appropriate for use in forensic and paternity testing for this population. Iraq is similar to other countries in the Middle East, particularly Iran and Turkey, and is more similar to Europe than either Asia or Africa.

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根据 15 个基因位点分析伊拉克 6 个城市的短串联重复序列(STR)变异。
背景:从伊拉克的安巴尔、巴格达、巴士拉、迪亚拉、纳杰夫和瓦西特等城市抽取了 161 个样本,并对 15 个法医 STR 进行了分型,以探索伊拉克的基因结构并建立法医 DNA 数据库。鉴定出的等位基因总数为 203.结果:然后进行了分子方差分析(AMOVA) 巴格达的情况很好地代表了伊拉克其他地区的情况,而安巴尔的遗传特征则最为明显。这些位点的平均杂合度为 0.779,同质性为 0.221,多态性信息含量为 0.77,区分度为 0.927,排除度为 0.563。在这些位点上,平均每 8.152 × 1017 个个体中就会出现 1 个匹配的基因型。在亲子鉴定中,匹配图谱的平均亲子概率为 99.9997%:这些基因位点适合用于该人群的法医和亲子鉴定。伊拉克与中东其他国家(尤其是伊朗和土耳其)相似,与欧洲的相似程度高于亚洲或非洲。
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