{"title":"Proapoptotic protein Bim regulates the suppressive function of Treg cells.","authors":"Di Wu","doi":"10.1631/jzus.B2300288","DOIUrl":null,"url":null,"abstract":"<p><p>Regulatory T (Treg) cells are a special immunosuppressive subset of cluster of differentiation 4-positive (CD4<sup>+</sup>)-T lymphocytes and play a pivotal role in the establishment of immune homeostasis in vivo (Zhang et al., 2021). The transcription factor forkhead box protein P3 (Foxp3) is the master marker of Treg cells, which is highly expressed in Treg cells and is also essential for their suppressive function (Hori et al., 2003). In addition to Foxp3, other regulators of Treg cells have been discovered (Wu et al., 2017, 2022; Wu and Sun, 2023a, 2023b); however, a deeper understanding of the regulation of these cells is required.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"24 12","pages":"1180-1184"},"PeriodicalIF":4.7000,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710911/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Zhejiang University SCIENCE B","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1631/jzus.B2300288","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Regulatory T (Treg) cells are a special immunosuppressive subset of cluster of differentiation 4-positive (CD4+)-T lymphocytes and play a pivotal role in the establishment of immune homeostasis in vivo (Zhang et al., 2021). The transcription factor forkhead box protein P3 (Foxp3) is the master marker of Treg cells, which is highly expressed in Treg cells and is also essential for their suppressive function (Hori et al., 2003). In addition to Foxp3, other regulators of Treg cells have been discovered (Wu et al., 2017, 2022; Wu and Sun, 2023a, 2023b); however, a deeper understanding of the regulation of these cells is required.
调节性T (Regulatory T, Treg)细胞是分化4阳性(CD4+)淋巴细胞簇的一种特殊的免疫抑制亚群，在体内免疫稳态的建立中起着关键作用(Zhang et al.， 2021)。转录因子叉头盒蛋白P3 (Foxp3)是Treg细胞的主标记物，在Treg细胞中高度表达，对Treg细胞的抑制功能也至关重要(Hori et al.， 2003)。除了Foxp3外，还发现了Treg细胞的其他调节因子(Wu et al.， 2017,2022;吴、孙，2023a, 2023b);然而，需要对这些细胞的调控有更深入的了解。
期刊介绍：
Journal of Zheijang University SCIENCE B - Biomedicine & Biotechnology is an international journal that aims to present the latest development and achievements in scientific research in China and abroad to the world’s scientific community.
JZUS-B covers research in Biomedicine and Biotechnology and Biochemistry and topics related to life science subjects, such as Plant and Animal Sciences, Environment and Resource etc.
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