Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-02-01 Epub Date: 2023-12-07 DOI:10.1037/hea0001267

Kieran Ayling, Michaela Brown, Sophie Carlisle, Robert Bennett, Heather Buchanan, Jennifer Dumbleton, Christopher Hawkey, Katja Hoschler, Ruth H Jack, Jonathan Nguyen-Van-Tam, Simon Royal, David Turner, Maria Zambon, Lucy Fairclough, Kavita Vedhara

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Abstract

Objective: This trial explored the psychological and immunological effects of two brief interventions, targeting improving positive mood, administered to older adults immediately prior to influenza vaccination. The primary aim was to examine whether the interventions resulted in greater positive mood compared to usual care, and if so, which was superior. Secondary outcomes included antibody responses to vaccination and feasibility of collecting clinical outcome data (e.g., respiratory infections).

Method: Six hundred and fifty-four older adults (65-85 years) participated in a three-arm, parallel, randomized controlled trial between September 2019 and May 2020. Immediately prior to receiving an adjuvanted trivalent influenza vaccine (Fluad, Seqirus UK Ltd), participants viewed one of two brief (15-min) video-based positive mood interventions (one fixed content, one allowing participant choice) or received usual care. State affect was measured immediately prior to, and following, intervention exposure or usual care. Antibody responses were measured prevaccination and 4 weeks postvaccination. Clinical outcomes were extracted from primary care records for 6 months following vaccination.

Results: Both interventions were equally effective at improving mood prior to vaccination compared to usual care. Antibody responses were highly robust with postvaccination seroprotection rates of > 88% observed for all vaccine strains. Antibody responses did not significantly differ between groups. Clinical outcome data were feasible to collect.

Conclusions: Brief psychological interventions can improve mood prior to vaccination. However, altering antibody responses to highly immunogenic adjuvanted vaccines may require more targeted or prolonged interventions. The provision of choice did not notably enhance the interventions impact on mood or antibody outcomes. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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老年人流感疫苗接种前的情绪优化:一项三组随机对照试验

目的:本试验探讨了两种简短干预措施的心理和免疫效果，旨在改善积极情绪，在接种流感疫苗之前立即给予老年人。研究的主要目的是检查干预是否比常规治疗产生更大的积极情绪，如果是，哪一种更优越。次要结局包括对疫苗接种的抗体反应和收集临床结局数据的可行性(如呼吸道感染)。方法:2019年9月至2020年5月期间，654名老年人(65-85岁)参加了一项三臂、平行、随机对照试验。在接受三价流感佐剂疫苗(Fluad, Seqirus UK Ltd)之前，参与者观看了两个简短(15分钟)基于视频的积极情绪干预(一个固定内容，一个允许参与者选择)中的一个或接受常规护理。状态影响是在干预暴露或常规护理之前和之后立即测量的。分别在接种前和接种后4周检测抗体应答。从接种疫苗后6个月的初级保健记录中提取临床结果。结果:与常规护理相比，两种干预措施在改善疫苗接种前的情绪方面同样有效。所有疫苗株接种后血清保护率均> 88%，抗体应答高度稳定。各组间抗体反应无显著差异。临床结果数据的收集是可行的。结论:简短的心理干预可以改善疫苗接种前的情绪。然而，改变抗体对高免疫原性佐剂疫苗的反应可能需要更有针对性或更长时间的干预。提供选择并没有显著增强干预对情绪或抗体结果的影响。(PsycInfo数据库记录(c) 2023 APA，版权所有)。

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