Enhanced fluctuation in heterogeneous chromatic medium emerging by transient-linking activity

Abstract

Spatiotemporal coordination of chromatin and subnuclear compartments is crucial for cells. A plethora of enzymes act inside nucleus, and some of those transiently link two chromatin segments. Here, we theoretically study how such transient-linking activities affect fluctuating dynamics of an inclusion in the chromatic medium. Numerical simulations and a coarse-grained model analysis categorize inclusion dynamics into three distinct modes. The transient-linking activity speeds up the inclusion dynamics by affecting a slow mode associated with chromatin remodeling, viz., size and shape of the chromatin meshes.