Advances and Perspectives of Responsive Probes for Measuring γ-Glutamyl Transpeptidase

IF 4.6 Q1 CHEMISTRY, ANALYTICAL ACS Measurement Science Au Pub Date : 2023-12-04 DOI:10.1021/acsmeasuresciau.3c00045
Yiming Zhang, Zexi Zhang, Miaomiao Wu and Run Zhang*, 
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Abstract

Gamma-glutamyltransferase (GGT) is a plasma-membrane-bound enzyme that is involved in the γ-glutamyl cycle, like metabolism of glutathione (GSH). This enzyme plays an important role in protecting cells from oxidative stress, thus being tested as a key biomarker for several medical conditions, such as liver injury, carcinogenesis, and tumor progression. For measuring GGT activity, a number of bioanalytical methods have emerged, such as chromatography, colorimetric, electrochemical, and luminescence analyses. Among these approaches, probes that can specifically respond to GGT are contributing significantly to measuring its activity in vitro and in vivo. This review thus aims to highlight the recent advances in the development of responsive probes for GGT measurement and their practical applications. Responsive probes for fluorescence analysis, including “off–on”, near-infrared (NIR), two-photon, and ratiometric fluorescence response probes, are initially summarized, followed by discussing the advances in the development of other probes, such as bioluminescence, chemiluminescence, photoacoustic, Raman, magnetic resonance imaging (MRI), and positron emission tomography (PET). The practical applications of the responsive probes in cancer diagnosis and treatment monitoring and GGT inhibitor screening are then highlighted. Based on this information, the advantages, challenges, and prospects of responsive probe technology for GGT measurement are analyzed.

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γ-谷氨酰转肽酶响应探针的研究进展与展望
γ-谷氨酰转移酶(GGT)是一种质膜结合酶,参与γ-谷氨酰循环,如谷胱甘肽(GSH)的代谢。这种酶在保护细胞免受氧化应激方面起着重要作用,因此被测试为几种医学状况的关键生物标志物,如肝损伤、致癌和肿瘤进展。为了测量GGT活性,出现了许多生物分析方法,如色谱法、比色法、电化学和发光分析。在这些方法中,能够特异性响应GGT的探针在体外和体内测量其活性方面做出了重大贡献。因此,本综述旨在强调用于GGT测量的响应探针的发展及其实际应用的最新进展。本文首先总结了用于荧光分析的响应探针,包括“开关”、近红外(NIR)、双光子和比例荧光响应探针,然后讨论了其他探针的发展进展,如生物发光、化学发光、光声、拉曼、磁共振成像(MRI)和正电子发射断层扫描(PET)。然后重点介绍了反应性探针在癌症诊断和治疗监测以及GGT抑制剂筛选中的实际应用。在此基础上,分析了响应式探针技术在GGT测量中的优势、挑战和前景。
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ACS Measurement Science Au
ACS Measurement Science Au 化学计量学-
CiteScore
5.20
自引率
0.00%
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0
期刊介绍: ACS Measurement Science Au is an open access journal that publishes experimental computational or theoretical research in all areas of chemical measurement science. Short letters comprehensive articles reviews and perspectives are welcome on topics that report on any phase of analytical operations including sampling measurement and data analysis. This includes:Chemical Reactions and SelectivityChemometrics and Data ProcessingElectrochemistryElemental and Molecular CharacterizationImagingInstrumentationMass SpectrometryMicroscale and Nanoscale systemsOmics (Genomics Proteomics Metabonomics Metabolomics and Bioinformatics)Sensors and Sensing (Biosensors Chemical Sensors Gas Sensors Intracellular Sensors Single-Molecule Sensors Cell Chips Arrays Microfluidic Devices)SeparationsSpectroscopySurface analysisPapers dealing with established methods need to offer a significantly improved original application of the method.
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