Exploring the Role of Locus Coeruleus in Alzheimer’s Disease: a Comprehensive Update on MRI Studies and Implications

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY Current Neurology and Neuroscience Reports Pub Date : 2023-12-08 DOI:10.1007/s11910-023-01324-9

Alessandro Galgani, Filippo Sean Giorgi

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Abstract

Purpose of Review

Performing a thorough review of magnetic resonance imaging (MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer’s disease (AD), and contextualizing them with current preclinical and neuropathological literature.

Recent Findings

MRI successfully detected LC alterations in ageing and AD, identifying degenerative phenomena involving this nucleus even in the prodromal stages of the disorder. The degree of LC disruption was also associated with the severity of AD cortical pathology, cognitive and behavioral impairment, and the risk of clinical progression.

Summary

Locus coeruleus-MRI has proved to be a useful tool to assess the integrity of the central noradrenergic system in vivo in humans. It allowed to test in patients preclinical and experimental hypothesis, thus confirming the specific and marked involvement of the LC in AD and its key pathogenetic role. Locus coeruleus-MRI–related data might represent the theoretical basis on which to start developing noradrenergic drugs to target AD.

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探索大脑灶在阿尔茨海默病中的作用：核磁共振成像研究的全面更新及其影响

综述目的对磁共振成像（MRI）研究进行全面综述，评估老龄化和阿尔茨海默病（AD）中位置小脑（LC）的完整性，并将其与当前的临床前和神经病理学文献结合起来。Locus coeruleus-MRI 已被证明是评估体内中枢去甲肾上腺素能系统完整性的有效工具。它允许在患者身上测试临床前和实验假设，从而证实了嗜铬细胞在注意力缺失症中的特异性和明显参与及其关键的致病作用。与Locus coeruleus-MRI相关的数据可能是开始开发针对AD的去甲肾上腺素能药物的理论基础。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.

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